Day: November 1, 2022

On November 7, 2019, Tarby, Christine M.; Norris, Derek J.; Lo, Julian C.; Ahuja, Vijay T.; Seitz, Steven P.; Gavai, Ashvinikumar V.; Tokarski, John S.; Rajasagi, Mohini; Wichroski, Michael; Broekema, Matthias published a patent.HPLC of Formula: 64987-16-2 The title of the patent was Preparation of uracil derivatives as Mer-Axl inhibitors. And the patent contained the following:

The invention relates generally to compounds I [Ar1 = aryl or heteroaryl containing 1-4 heteroatoms selected from N, O or S; Ar2 = heteroaryl containing 1-4 heteroatoms selected from N, O or S; Q1 = NHCO, CONH, NHSO2, etc.; Q2 = O or NH; R1 and R2 = (independently) H, (un)substituted alkyl, (CH2)r(cycloalkyl), etc.; R3 and R4 = (independently) H, halo, CF3, etc.; X and Y = (independently) H, halo, alkyl, etc.; r = 0-2] or pharmaceutically acceptable salts, tautomers or stereoisomers thereof, that are Mer-Axl inhibitors, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention. Over one-hundred-forty compounds I were prepared E.g., a multi-step synthesis of II, starting from di-Et 2-(aminomethylene)malonate and 1-fluoro-4-isocyanatobenzene, was described. The inhibitory activity of compounds I was tested in the MERTK, AXL, and TYRO3 activity assays (data given for representative compounds I). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).HPLC of Formula: 64987-16-2

The Article related to uracil derivative preparation mer axl tyro3 kinase inhibitor antitumor, proliferative disorder dysregulated apoptosis treatment uracil derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nagaladinne, Nizamuddin; Abdul Ahad, Hindustan; Nayakanti, Devanna published an article in 2020, the title of the article was Design, synthesis and molecular modelling studies of 1-methyl-3-(4-substituted phenyl-1,3- thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazolin-4(1H)-ones as potent anticancer agents.Electric Literature of 2010-06-2 And the article contains the following content:

The present study involved the design, synthesis, characterization and mol. docking studies of biol. active 1-methyl-3-(4-substituted phenyl-1,3-thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazoline-4-(1H)-ones I [R = 2-OH, 3-NH2, 4-Cl, etc.] which were synthesized by condensation of 2-amino-4-substituted phenylthiazoles with N-methylbenzoxazin-4-one. The N-methylbenzoxazin-4-one and 2-amino-4-substituted phenylthiazoles were synthesized from N-methylanthranilic acid with pyridine3-carboxylic acid and substituted aldehydes with thiourea, resp. The ADME properties determined the synthetic accessibility of compounds I by in silico Swiss ADME. The colorectal anticancer screening of compounds I was done by using cell HT-29 human colorectal adenocarcinoma based on mol. docking studies on 3GC7-the structure of p38alpha in complex with dihydroquinazolinone. Finally, compounds I [R = 4-Me, 3-NH2, 2,4-(OH)2, 2,4-(Cl)2] exhibited better activity at a concentration < 10μg/mL when compared to 5-fluorouracil. The ADME properties revealed that all the compounds I were within the range and docking studies showed the highest binding with glide score -7.19 and -7.027 Kcal/mol compared to the target protein -10.67 Kcal/mol. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to methyl phenyl thiazolyl pyridinyl dihydroquinazolinone preparation antitumor sar admet, mol modeling methyl phenyl thiazolyl pyridinyl dihydroquinazolinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2019, Rezania, Jafar; Hayatipour, Mohammad; Shockravi, Abbas; Ehsani, Morteza; Vatanpour, Vahid published an article.Product Details of 2010-06-2 The title of the article was Synthesis and characterization of soluble aromatic polyamides containing double sulfide bond and thiazole ring. And the article contained the following:

Novel diamine containing thiazole ring and double sulfide bond was synthesized, and the related polyamides were prepared by a direct polycondensation reaction of this diamine and various aromatic diacids. The polyamides were obtained in good yields and were characterized by differential scanning calorimetry, thermal gravimetric anal., Fourier transform IR, viscosity, solubility, and elemental anal. The glass transition temperatures of synthesized polyamides were in the range of 120-192 °C. The inherent viscosity of these polyamides was in the range of 0.4-0.62 dL/g. The solubility of these polyamides was investigated in some solvents such as DMSO, N-methyl-2-pyrrolidinone, and N,N-dimethylformamide. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Product Details of 2010-06-2

The Article related to aromatic polyamide sulfide bond thiazole ring, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Product Details of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Rezania, Hamidreza published an article in 2020, the title of the article was Synthesis and characterization of novel functional hyperbranched polyamides from AB2 units: effect of extra functional groups.Category: thiazole And the article contains the following content:

Hyperbranched polymers (HPs), which in terms of structure may be compared to the branching structure of trees, are referred to as tree-like materials, but role of leave in these tree-like polymers is neglected and much attention has only been paid to their branches. In fact, functional groups in these polymers play a vital role the same as the role of leaves in trees. Therefore, in this paper, an attempt has been made to design and synthesize three AB2 monomers containing extra hydroxyl and nitro groups. The benefits of their presence in the structure of produced hyperbranched polyamides (HPs) are investigated. The polymer structure was characterized by FT-IR and 1 H NMR. The solubility of synthesized HPs was studied in different protic and aprotic solvents. The thermal stability of the prepared HPs was investigated by thermogravimetric and differential scanning calorimetric analyses. The photoluminescent properties of the HPs were also investigated. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Category: thiazole

The Article related to hyperbranched polyamide preparation thermal property, novel ab2 monomers, functional groups, hyperbranched polymers, polyamide, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jiang, Yi-Min; Yu, Yi; Wu, Shao-Fen; Yan, Hong; Yuan, Yaofeng; Ye, Ke-Yin published an article in 2021, the title of the article was Electrochemical fluorosulfonylation of styrenes.Formula: C5H5NOS And the article contains the following content:

An environmentally friendly and efficient electrochem. fluorosulfonylation of styrenes were developed. With the use of sulfonylhydrazides and triethylamine trihydrofluoride, a diverse array of β-fluorosulfones were readily obtained. This reaction featured mild conditions and a broad substrate scope, which was conveniently extended to a gram-scale preparation The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to fluoro arylsulfone preparation, arylsulfonyl hydrazide terminal arylalkene electrochem fluorosulfonylation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 29, 2020, Poisson, Luigi; Pittet, Jonathan; Schaerer, Anja; Mestdagh, Frederic; Davidek, Tomas published an article.Product Details of 24295-03-2 The title of the article was Quantitative Validation of the In-Bean Approach in Coffee Roasting. And the article contained the following:

The representativeness of the so-called biomimetic “in-bean” technique was studied by following the formation of target aroma compounds during the roasting course (10 points from 0 to 400 s) in recombined coffee beans and non-treated green coffee reference beans. For this purpose, the water-soluble fraction was replaced by a biomimetic recombinate in reconstituted beans prior to roasting. The targeted anal. of key aroma compounds was performed by means of the stable isotope dilution assay and solid-phase microextraction-gas chromatog.-mass spectrometry of roasted and ground coffee samples. The results were compared to the quant. data on a green coffee reference roasted under the same conditions. The results showed similar formation kinetics for most of the evaluated volatiles, such as Strecker aldehydes, alkylpyrazines, or α-diketones. In addition, the final quantities of key odorants in both types of samples were quite comparable. Hence, the refined biomimetic approach was validated as a valuable tool in studying different aspects of flavor formation upon coffee roasting. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Product Details of 24295-03-2

The Article related to coffee bean roasting model, maillard reaction, coffee flavor formation, kinetics, precursors, roasting, Food and Feed Chemistry: Physical, Organic, and Inorganic Chemistry and Model Systems and other aspects.Product Details of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica