On June 7, 2018, Wunderlich, Winfried; Huber, Lukas A.; Leban, Johann Jakob; Pato, Janos; Oerfi, Laszlo; Frigyes, Waczek; Banhegyi, Peter; Sipos, Anna; Szantai-Kis, Csaba published a patent.Category: thiazole The title of the patent was Preparation of 3-amino-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones as cyclin dependent kinase inhibitors for the treatment and prophylaxis of cancer. And the patent contained the following:
The invention relates to preparation of pyrazolopyrimidinones of formulas I and II wherein X1 and X4 each independently H, halo, C1-6 alkoxy; X2 is H or halo; X3 is H, COOH, etc., as cyclin dependent kinase (CDK) inhibitors, pharmaceutical compositions comprising the same and the use thereof in particular in the prophylaxis and treatment of cancer and other proliferative diseases. Furthermore the invention relates to processes for the preparation of said 3-amino-pyrazolo[3,4d]pyrimidin-4-ones and intermediates to be used in the processes of the invention. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Category: thiazole
The Article related to pyrazolopyrimidinone preparation cdk inhibitor proliferative disease cancer treatment prophylaxis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica