Campaigne, E.; Selby, T. P. published an article in 1980, the title of the article was Reactions of 4-chloroacetoacetic esters with thioureas.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate And the article contains the following content:
Thiazoles I (R = Me, Et) were prepared in 61 and 83% yields, resp., by cyclizing ClCH2COCH2CO2R (II) with H2NCSNH2. Cyclizing II with III (n = 1, 2) gave 50-88% IV. Hydrolysis of IV (R = Et) gave IV (R = H). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to thiazoleacetate, chloroacetoacetate thiourea cyclization, imidazolethiazole acetate, thiazolopyrimidine acetate, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica