On September 8, 2010, Fang, Weizheng; Zhang, Hongjian; Qian, Dongbo published a patent.COA of Formula: C6H8N2O2S The title of the patent was Method for synthesis of Ceftibuten side chain from 2-aminothiazolylacetic acid. And the patent contained the following:
A process for preparation of Ceftibuten side chain I from 2-aminothiazolylacetic acid via carboxylic group protection, amino protection, hydroxymethylation, Wittig reaction, and mono esterification in five steps (detail procedure given) is disclosed. The process has advantages of no employment of expensive Me 3-methoxyacrylate, lower cost, reduced pollution to environment, simple process, good controllability, high and stable yield, suitability for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).COA of Formula: C6H8N2O2S
The Article related to ceftibuten side chain preparation aminothiazolylacetic acid hydroxymethylation wittig esterification, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C6H8N2O2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica