On May 31, 2020, Hussein, Essam M.; Al-Rooqi, Munirah M.; Elkhawaga, Amal A.; Ahmed, Saleh A. published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was Tailoring of novel biologically active molecules based on N4-substituted sulfonamides bearing thiazole moiety exhibiting unique multi-addressable biological potentials. And the article contained the following:
In the present study, a new series of 2-(4-substituted-thiazol-2-ylamino)acetamides and N-(4-substituted-thiazol-2-yl)acetamides incorporating sulfonamide moieties I (R = H, 4-bromophenyl, pyren-1-yl, etc.; R1 = CH2C(O), C(O)CH2; X = CH2, O) was designed, synthesized, well-characterized and successfully evaluated for their antimicrobial activity against multidrug resistant strains and screened for cytotoxic activity against normal lung fibroblast (WI-38), human lung carcinoma (A549), and human breast carcinoma (MDA-MB-231) cell lines. Fluorescence-activated cell sorting (FACS) anal. and mol. modeling study were performed to identify the mode of action of the novel synthesized compounds and their binding interactions with the active sites of dihydrofolate reductase enzyme (DHFR). The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine
The Article related to acetamide aminothiazolyl sulfonyl preparation docking antibacterial antifungal antitumor activity, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Reference of 4-Phenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica