Day: November 2, 2022

On June 5, 2019, Zarnegar, Zohre; Shokrani, Zahra; Safari, Javad published an article.HPLC of Formula: 2010-06-2 The title of the article was Asparagine functionalized Al2O3 nanoparticle as a superior heterogeneous organocatalyst in the synthesis of 2-aminothiazoles. And the article contained the following:

Asparagine functionalized aluminum oxide nanoparticles (Asp-Al2O3) have been prepared by a two-step procedure involving the grafting of Al2O3 with 3-chloropropyltrimethoxysilane (CPTMS) and subsequent organofunctionalization using asparagine amino acid. It is shown that Asp-Al2O3 exhibits as an active nanocatalyst for the preparation of 2-aminothiazoles is achieved by one-pot reaction of methylcarbonyls, thiourea and iodine. The structure of Asp-Al2O3 was characterized by fourier transform IR radiation (FT-TR), thermal gravimetric anal. (TGA), X-ray diffraction (XRD), scanning electron microscopic (SEM), and energy-dispersive anal. of X-ray (EDAX) analyses. Advantages of this modified methodol. include higher purity and excellent yield of products, greener and cleaner conditions, easy isolation of products and convenient manipulation. Moreover, immobilization of organocatalysts on the Al2O3 surface are stable under the catalytic reaction conditions resulting their efficient reuse. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).HPLC of Formula: 2010-06-2

The Article related to asparagine aluminum oxide nanoparticle preparation, aminothiazole preparation green chem, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.HPLC of Formula: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 15, 2007, Srinivas, Akella Satya Surya Visweswara; Mathiyazhagan, Kasinathan; Sharada, Duddu Savaraiah; Ponpandian, Thanasekaran; Revathy, Kulasekharan; Reddy, Gaddam Om; Kamaraj, Mani; Rajagopal, Sriram published a patent.Name: Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of heterocyclic compounds as inhibitors of histone deacetylase for treatment of cancer. And the patent contained the following:

The title heterocyclic compounds with general formula of A-(CH2)m-O-C(=X)-NH-(CH2)n-E-(CH2)p-C(=Y)-N(R1)R2 [wherein A and E = independently (hetero)aryl, arylalkyl, or benzo-fused heteroaryl, etc.; X and Y = independently O, S, or (un)substituted NH; R1 and R2 = independently H, OH, alkoxy, arylalkyl, etc.; or R1 and R2 form a ring; m, n, and p = independently 0-2], or derivatives, analogs, stereoisomers, and pharmaceutically acceptable salts thereof were prepared as inhibitors of histone deacetylase (HDAC) for treatment of cancer. For example, I was prepared in a multi-step synthesis. I showed inhibitory activity with IC50 of 0.021 μM against HDAC. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Name: Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to preparation heterocyclic compound thiazole inhibitor histone deacetylase treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Name: Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 5, 2018, Ma, Chunhua; Miao, Yuqi; Zhao, Minghao; Wu, Ping; Zhou, Jianglu; Li, Zhi; Xie, Xilei; Zhang, Wei published an article.Recommanded Product: 31699-14-6 The title of the article was Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydantoin (DBH). And the article contained the following:

An efficient procedure for the synthesis of 2-aminothiazoles via DBH-mediated oxidative cyclization of styrenes and thioureas is reported. Various alkenes were successfully transformed to the corresponding 2-aminothiazoles in yields of 10-81% via a two-step one-pot manner using DBH as both the bromine source and oxidant. The method can be readily carried out in gram-scale and successfully applied to the synthesis of anti-inflammatory drug fanetizole using styrene as starting material. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Recommanded Product: 31699-14-6

The Article related to aminothiazole preparation, styrene thiourea oxidative cyclization dibromo dimethylhydantoin, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2011, Hathoot, A. A.; El-Maghrabi, S.; Abdel-Azzem, M. published an article.Recommanded Product: 92-36-4 The title of the article was Electrochemical and electrocatalytic properties of hybrid films composed of conducting polymer and metal hexacyanoferrate. And the article contained the following:

Hybrid organic/inorganic modified electrode, composed of poly(2-(4-aminophenyl)-6-methylbenzothiazole) (PABT) matrix and Prussian blue (PB) like Ni hexacyanoferrate redox centers (PABT/NiHcF), showed reversible electrochem. behavior in aqueous electrolytes. Pt disk (Pt) was used as a conductive substrate onto which the composite film was electrodeposited by potential cycling. Electrochem. behavior of the modified electrode was well characterized using cyclic voltammetry (CV). The voltammetric characteristics of the composite modified electrodes were also studied in presence of different alkali metal cations (Li+, Na+, K+ ,Ce+ and NH4+). The heterogeneous electron transfer processes involving the composite and their stability were examined by subjecting the system to the long term cyclic voltammetric potential, cycling in 0.2 M NaCl electrolyte. Bilayer composite electrodes exhibit higher ionic conductivity, higher stability in comparison with pure inorganic (MeHcF) films. The inner electro active polymer chains in the film cause enhancement in the elec. conductivity of the composite electrodes. The modified electrode presented a good electrocatalytic activity towards the oxidation of MeOH, and oxalic acid (COOH)2. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Recommanded Product: 92-36-4

The Article related to electrochem electrocatalysis hybrid film composed conducting polymer metal hexacyanoferrate, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Recommanded Product: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2021, Zhang, Qian; Wu, Jiefei; Pan, Zexi; Zhang, Wen; Zhou, Wei published an article.Quality Control of 4-Phenylthiazol-2-amine The title of the article was A one-pot synthesis of 2-aminothiazoles via the coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system. And the article contained the following:

A series of 2-aminothiazoles was prepared in moderate-to-good yields by the direct coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system. This method avoids the preparation of lachrymatory and toxic α-haloketones and the use of an acid-binding agent, thus provided a more convenient approach to 2-aminothiazoles compared to the Hantzsch reaction. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Quality Control of 4-Phenylthiazol-2-amine

The Article related to ketone thiourea iodine catalyst dimethyl sulfoxide oxidative coupling, aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 31, 2020, Hussein, Essam M.; Al-Rooqi, Munirah M.; Elkhawaga, Amal A.; Ahmed, Saleh A. published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was Tailoring of novel biologically active molecules based on N4-substituted sulfonamides bearing thiazole moiety exhibiting unique multi-addressable biological potentials. And the article contained the following:

In the present study, a new series of 2-(4-substituted-thiazol-2-ylamino)acetamides and N-(4-substituted-thiazol-2-yl)acetamides incorporating sulfonamide moieties I (R = H, 4-bromophenyl, pyren-1-yl, etc.; R1 = CH2C(O), C(O)CH2; X = CH2, O) was designed, synthesized, well-characterized and successfully evaluated for their antimicrobial activity against multidrug resistant strains and screened for cytotoxic activity against normal lung fibroblast (WI-38), human lung carcinoma (A549), and human breast carcinoma (MDA-MB-231) cell lines. Fluorescence-activated cell sorting (FACS) anal. and mol. modeling study were performed to identify the mode of action of the novel synthesized compounds and their binding interactions with the active sites of dihydrofolate reductase enzyme (DHFR). The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine

The Article related to acetamide aminothiazolyl sulfonyl preparation docking antibacterial antifungal antitumor activity, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Reference of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ma, Dawei; Xie, Siwei; Xue, Peng; Zhang, Xiaojing; Dong, Jinhua; Jiang, Yongwen published an article in 2009, the title of the article was Efficient and economical access to substituted benzothiazoles: copper-catalyzed coupling of 2-haloanilides with metal sulfides and subsequent condensation.SDS of cas: 92-36-4 And the article contains the following content:

The first metal-catalyzed direct coupling of metal sulfides with aryl halides and subsequent intramol. condensation provided substituted benzothiazoles. A wide range of functional groups are tolerated under the reaction conditions. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).SDS of cas: 92-36-4

The Article related to benzothiazole derivative preparation, haloanilinde metal sulfide coupling copper cyclocondensation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 23, 2020, de Andrade, Vitor S. C.; de Mattos, Marcio C. S. published an article.Formula: C9H8N2S The title of the article was One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid. And the article contained the following:

A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48-70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Formula: C9H8N2S

The Article related to aryl aminothiazole preparation tribromoisocyanuric acid promoter, styrene thiourea tandem reaction, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 8, 2010, Fang, Weizheng; Zhang, Hongjian; Qian, Dongbo published a patent.COA of Formula: C6H8N2O2S The title of the patent was Method for synthesis of Ceftibuten side chain from 2-aminothiazolylacetic acid. And the patent contained the following:

A process for preparation of Ceftibuten side chain I from 2-aminothiazolylacetic acid via carboxylic group protection, amino protection, hydroxymethylation, Wittig reaction, and mono esterification in five steps (detail procedure given) is disclosed. The process has advantages of no employment of expensive Me 3-methoxyacrylate, lower cost, reduced pollution to environment, simple process, good controllability, high and stable yield, suitability for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).COA of Formula: C6H8N2O2S

The Article related to ceftibuten side chain preparation aminothiazolylacetic acid hydroxymethylation wittig esterification, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C6H8N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Poola, Sreelakshmi; Gundluru, Mohan; Nadiveedhi, Maheshwara Reddy; Saddala, Madhu Sudhana; P. T. S. R. K., Prasada Rao; Cirandur, Suresh Reddy published an article in 2020, the title of the article was Nano silver particles catalyzed synthesis, molecular docking and bioactivity of α-thiazolyl aminomethylene bisphosphonates.Recommanded Product: 4-Phenylthiazol-2-amine And the article contains the following content:

A new series of α-thiazolyl aminomethylene bisphosphonates I (R1 = H, OCH3, F, Br; R2 = OMe, OEt, OBu, OPh)were synthesized by a three component reaction of 4-aryl substituted thiazol-2-amine with different dialkyl/aryl phosphites and tri-Et orthoformate in the presence of Ag NPs (nano particles) as a catalyst under solvent free conditions. The target compounds were screened for their in vitro antioxidant, antibacterial and antifungal activity. Mol. docking studies were also performed. The results revealed that among the synthesized compounds I (R1 = OCH3, F, Br; R2 = Me) showed remarkably higher antioxidant activity by DPPH and H2O2 than the standard ascorbic acid. Compounds I (R1 = H, OCH3, F; R2 = Me) showed good antibacterial activity and also showed rather higher antifungal activity than the standard flucanozole. Computational docking methods have been used to predict how several aminomethylene bisphosphonate derivatives compete against the inhibitor BPH-1330 at the crystal enzyme structure of the 4H3A protein active site and how substituents influence their binding ability. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to thiazolyl aminomethylene bisphosphonate preparation mol docking antioxidant antibacterial antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica