Day: November 2, 2022

On June 22, 2022, Liang, Xiao-Ping; Luo, Min; Kang, Li; Tang, Long-Xing; Liang, Qing; Liu, Yuan-Lin; Yang, Zi; Zhang, Chun-Tao; Peng, Cai-Yun; Fu, Rong-Geng published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was Facile one-pot three-component strategy for the synthesis of 2-amino-4-arylthiazoles via elemental sulfur source. And the article contained the following:

A novel and facile metal-free method for the green synthesis of 2-amino-4-arylthiazole derivatives I (Ar = 3-nitrophenyl, 2-naphthyl, pyridin-4-yl, etc.) through the three-component cascade reaction of aromatic Me ketones ArC(O)Me, elemental sulfur and cyanamide is reported. One C-N bond and two C-S bonds were formed in one-pot protocol without using catalysts. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine

The Article related to amino arylthiazole preparation green chem, aryl methyl ketone sulfur cyanamide three component cascade, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Reference of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 22, 2022, Liang, Xiao-Ping; Luo, Min; Kang, Li; Tang, Long-Xing; Liang, Qing; Liu, Yuan-Lin; Yang, Zi; Zhang, Chun-Tao; Peng, Cai-Yun; Fu, Rong-Geng published an article.Category: thiazole The title of the article was Facile one-pot three-component strategy for the synthesis of 2-amino-4-arylthiazoles via elemental sulfur source. And the article contained the following:

A novel and facile metal-free method for the green synthesis of 2-amino-4-arylthiazole derivatives I (Ar = 3-nitrophenyl, 2-naphthyl, pyridin-4-yl, etc.) through the three-component cascade reaction of aromatic Me ketones ArC(O)Me, elemental sulfur and cyanamide is reported. One C-N bond and two C-S bonds were formed in one-pot protocol without using catalysts. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to amino arylthiazole preparation green chem, aryl methyl ketone sulfur cyanamide three component cascade, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Safari, Javad; Shokrani, Zahra; Zarnegar, Zohre published an article in 2020, the title of the article was Asparagine as a Green Organocatalyst for the Synthesis of 2-Aminothiazoles.Synthetic Route of 2010-06-2 And the article contains the following content:

In this research, an efficient method for the one-pot synthesis of 2-aminothiazoles via reaction of thiourea with methylcarbonyls in the presence of iodine as an oxidant reagent has been developed using asparagine as a green organocatalyst at 80° in DMSO solvent. Advantages of this efficient method include greener and cleaner conditions, easy isolation of products, higher purity and excellent yield of products, and convenient manipulation. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to aminothiazole preparation green chem, methylcarbonyl thiourea cyclocondensation asparagine organocatalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2022, Li, Pei; Yang, Shang-Feng; Fang, Zi-Lin; Cui, Hao-Ran; Liang, Sen; Tian, Hong-Yu; Sun, Bao-Guo; Zeng, Cheng-Chu published an article.Synthetic Route of 2010-06-2 The title of the article was An efficient one-pot synthesis of 2-aminothiazoles via electrochemically oxidative α-C-H functionalization of ketones with thioureas. And the article contained the following:

An efficient one-pot electrochem. protocol for the synthesis of 2-aminothiazoles was described from electrolysis of ketones with thioureas mediated by iodide ion. The electrochem. synthesis was conducted in an undivided cell equipped with graphite plates electrodes under constant current conditions. A diversity of aromatic and aliphatic ketones were suitable for the reaction, yielding the corresponding 2-aminothiazoles in satisfactory yields. Mechanistically, the in-situ generated α-iodoketone was proposed to be a key active species. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to ketone thiourea ammonium iodide tandem electrooxidative cyclization green chem, aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shibasaki, Kaho; Togo, Hideo published an article in 2019, the title of the article was 2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas.Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole And the article contains the following content:

Treatment of alkylarenes with N-bromosuccinimide in a mixture of Et acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of di-Et carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino-4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, resp., in one pot [e.g., ethylbenzene + thiourea → 2-amino-4-phenylthiazole (84%)]. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole

The Article related to aminoarylthiazole synthesis alkylarene nbs thiourea, arylthiazole synthesis alkylarene nbs arenethioamide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shibasaki, Kaho; Togo, Hideo published an article in 2019, the title of the article was 2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas.Computed Properties of 2010-06-2 And the article contains the following content:

Treatment of alkylarenes with N-bromosuccinimide in a mixture of Et acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of di-Et carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino-4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, resp., in one pot [e.g., ethylbenzene + thiourea → 2-amino-4-phenylthiazole (84%)]. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Computed Properties of 2010-06-2

The Article related to aminoarylthiazole synthesis alkylarene nbs thiourea, arylthiazole synthesis alkylarene nbs arenethioamide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 5, 2021, Gorji, Samareh; Ghorbani-Vaghei, Ramin; Alavinia, Sedigheh published an article.Related Products of 2010-06-2 The title of the article was Sodium alginate: Biopolymeric catalyst for the synthesis of 2-amino-4-arylthiazole derivatives in aqueous medium. And the article contained the following:

An efficient and recoverable bifunctional heterogeneous organocatalyst for the synthesis of 2-amino-4-arylthiazole derivatives was carried out by the reaction of substituted Ph acetylene and thiourea in an eco-friendly condition in the presence of TBBDA. Mild reaction conditions, simple reaction procedure, easy purification, high yields of products, eco-friendly catalyst usage and convenient reusability were the highlighted points of this protocol. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Related Products of 2010-06-2

The Article related to aryl alkyne thiourea sodium alginate catalyst heterocyclization, amino arylthiazole preparation green chem, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2021, Ujwaldev, Sankuviruthiyil M.; Harry, Nissy Ann; Neetha, Mohan; Anilkumar, Gopinathan published an article.SDS of cas: 31699-14-6 The title of the article was Novel synthesis of 2-Aminothiazoles via Fe(III)-Iodine-catalyzed Hantzsch-type condensation. And the article contained the following:

A novel iron-iodine catalyzed one pot synthesis of 2-aminothiazoles I (Ar = Ph, 4-bromophenyl, furan-2-yl, etc.; R = H, Ph) from Me aryl ketones ArC(O)Me and thioureas RNHC(S)NH2 is demonstrated. This protocol can be considered as a catalyzed version of the classical Hantzsch aminothiazole synthesis I as it enables the in situ generation of α-iodoketones in the reaction medium using catalytic amount of iodine leading to Hantzsch condensation with thiourea. The supply of iodine for multiple catalytic cycles is ensured by using catalytic amounts of iron as it enables iodide to iodine oxidation The generality of this protocol is also well established in this manuscript by synthesizing a variety of 2-aminothiazoles I from different ketones and thiourea. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).SDS of cas: 31699-14-6

The Article related to aminothiazole preparation green chem, methyl aryl ketone thiourea hantzsch condensation iron iodine catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2021, Ujwaldev, Sankuviruthiyil M.; Harry, Nissy Ann; Neetha, Mohan; Anilkumar, Gopinathan published an article.Recommanded Product: 4-Phenylthiazol-2-amine The title of the article was Novel synthesis of 2-Aminothiazoles via Fe(III)-Iodine-catalyzed Hantzsch-type condensation. And the article contained the following:

A novel iron-iodine catalyzed one pot synthesis of 2-aminothiazoles I (Ar = Ph, 4-bromophenyl, furan-2-yl, etc.; R = H, Ph) from Me aryl ketones ArC(O)Me and thioureas RNHC(S)NH2 is demonstrated. This protocol can be considered as a catalyzed version of the classical Hantzsch aminothiazole synthesis I as it enables the in situ generation of α-iodoketones in the reaction medium using catalytic amount of iodine leading to Hantzsch condensation with thiourea. The supply of iodine for multiple catalytic cycles is ensured by using catalytic amounts of iron as it enables iodide to iodine oxidation The generality of this protocol is also well established in this manuscript by synthesizing a variety of 2-aminothiazoles I from different ketones and thiourea. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to aminothiazole preparation green chem, methyl aryl ketone thiourea hantzsch condensation iron iodine catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 27, 2022, Wang, Xingyi; Zhu, Yue; Zhou, Tingting; Yang, Weiqing; Fu, Haiyan; Chen, Hua; Ma, Menglin published an article.Application of 31699-14-6 The title of the article was Bromine-Mediated C-S Bond Formation: Synthesis of Thiazoles from α-Methylene Ketones by Using Oxone Oxidative System. And the article contained the following:

A novel method for the synthesis of various 2,4,5-trisubstituted thiazoles from methylketones and thiourea/thioacetamide/amidinothiourea using NaBr/Oxone oxidative system was developed. The three intimately connected advantages of this method, which form a whole, are that the reaction underwent a one-pot α-bromination/cyclization process, the use of more common methylene ketones as the raw material rather than α-halomethylene ketones and a cheap and easily available catalytic amount sodium bromide as the bromine source instead of stoichiometric bromine or NBS. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Application of 31699-14-6

The Article related to ethanone methanethioamide sodium bromide catalyst one pot bromination heterocyclization, thiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application of 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica