Day: November 2, 2022

On July 27, 2022, Wang, Xingyi; Zhu, Yue; Zhou, Tingting; Yang, Weiqing; Fu, Haiyan; Chen, Hua; Ma, Menglin published an article.Computed Properties of 2010-06-2 The title of the article was Bromine-Mediated C-S Bond Formation: Synthesis of Thiazoles from α-Methylene Ketones by Using Oxone Oxidative System. And the article contained the following:

A novel method for the synthesis of various 2,4,5-trisubstituted thiazoles from methylketones and thiourea/thioacetamide/amidinothiourea using NaBr/Oxone oxidative system was developed. The three intimately connected advantages of this method, which form a whole, are that the reaction underwent a one-pot α-bromination/cyclization process, the use of more common methylene ketones as the raw material rather than α-halomethylene ketones and a cheap and easily available catalytic amount sodium bromide as the bromine source instead of stoichiometric bromine or NBS. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Computed Properties of 2010-06-2

The Article related to ethanone methanethioamide sodium bromide catalyst one pot bromination heterocyclization, thiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Campaigne, E.; Selby, T. P. published an article in 1980, the title of the article was Reactions of 4-chloroacetoacetic esters with thioureas.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate And the article contains the following content:

Thiazoles I (R = Me, Et) were prepared in 61 and 83% yields, resp., by cyclizing ClCH2COCH2CO2R (II) with H2NCSNH2. Cyclizing II with III (n = 1, 2) gave 50-88% IV. Hydrolysis of IV (R = Et) gave IV (R = H). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to thiazoleacetate, chloroacetoacetate thiourea cyclization, imidazolethiazole acetate, thiazolopyrimidine acetate, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2015, Lei, Yingjie; Wu, Xinshi; Zhang, Guochun; Ai, Cuiling published an article.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Synthesis of 2-(4-aminophenyl)benzothiazoles using MF resin supported H+ under solvent free conditions. And the article contained the following:

A simple and convenient approach to 2-(4-aminophenyl)benzothiazole derivatives by condensation of o-aminothiophenol with (un)substituted p-aminobenzoic acid under the action of melamine formaldehyde resin (MFR) supported sulfuric acid under microwave irradiation (MW) and solvent-free conditions has been developed. Structures of the corresponding products were elucidated by IR, 1H NMR spectra, and elemental anal. The resin could be easily recovered and reused for subsequent reactions. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to aminophenyl benzothiazole preparation, aminothiophenol amino benzoic acid melamine formaldehyde resin cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 5, 2021, Sui, Yan-Fei; Ansari, Mohammad Fawad; Fang, Bo; Zhang, Shao-Lin; Zhou, Cheng-He published an article.Formula: C5H5NOS The title of the article was Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms. And the article contained the following:

Novel purinylthiazolylethanone derivatives, I [R = H, Et, allyl, 2-chlorophenylmethyl, etc], II [R1 = hydroxyl, hydroxyimino, methoxyimino]which were expected to combat the fungal drug resistance was developed. Some prepared purinylthiazolylethanone derivatives I and II possessed satisfactory inhibitory action towards the tested fungi, among which compound I [R = 2-ethoxyoxoethyl] gave a MIC value of 1μg/mL against C. albicans. The active mol. I [R = 2-ethoxyoxoethyl] was able to kill C. albicans with undetectable resistance as well as low hematotoxicity and cytotoxicity. Furthermore, it could hinder the growth of C. albicans biofilm, thus avoiding the occurrence of drug resistance. Mechanism research manifested that purinylthiazolylethanone derivative I [R = 2-ethoxyoxoethyl] led to damage of cell wall and membrane disruption, so protein leakage and the cytoplasmic membrane depolarization were observed On this account, the activity of fungal lactate dehydrogenase was reduced and metabolism was impeded. Meanwhile, the increased levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) disordered redox equilibrium, giving rise to oxidative damage to fungal cells and fungicidal effect. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to purinylthiazolylethanone preparation antifungal sar drug resistance, antifungal, drug resistance, purine, thiazole, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shaikh, Majid; Shaikh, Mujahed; Sheikh, Anis Ahmed; Kasim, Sayyad Sultan published an article in 2021, the title of the article was Synthesis of 4-aryl-2-aminothiazole using onion extract:a green chemistry approach.Formula: C9H8N2S And the article contains the following content:

The novel green and cost effective protocol was described for the synthesis of most important thiazole moiety by using onion extract as efficient solvent. The synthesis was performed by reaction between acetophenones and N-bromosuccinamide in onion juice medium followed by addition of thiourea. The easy work up ,shorter reaction time , environmentally benign and good to excellent yield of product were some specific features of this protocol. The results obtained were tabulated. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Formula: C9H8N2S

The Article related to acetophenone bromosuccinimide thiourea cyclocondensation ultrasonication green chem, amino phenylthiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 31, 2021, Chen, Yuncan; Lv, Shan; Lai, Ruizhi; Xu, Yingying; Huang, Xin; Li, Jianglian; Lv, Guanghui; Wu, Yong published an article.HPLC of Formula: 2010-06-2 The title of the article was Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas. And the article contained the following:

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, provided a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).HPLC of Formula: 2010-06-2

The Article related to sulfonium ylide thiourea rhodium catalyst chemoselective carbenoid insertion heterocyclization, aminothizaole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.HPLC of Formula: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica