On June 6, 2019, Quddus, Abdul; Novak, Andrew; Cousin, David; Chatzopoulou, Elli; Blackham, Emma; Jones, Geraint; Thomas, Jennifer; Wrigglesworth, Joseph; Duffy, Lorna; Birch, Louise; George, Pascal; Ahmed, Saleh published a patent.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of substituted sulfonamidothiazoles as CTRS1 inhibitors. And the patent contained the following:
The invention relates to compounds of formula I (wherein R1 is (un)substituted C1-5 alkyl and C0-2 alkyleneC3-5 cycloalkyl; R3 is H, halo, CH3, etc.; R4 and R5 are independently H, halo, C1-6 alkyl, etc.; R6 is H and C1-3 alkyl, etc.; Ar1 is 6-membered aryl and heteroaryl; Ar2 is 6-membered aryl and heteroaryl; R10 is H, halo, C1-3 alkyl, etc.; R11 is H, F, Cl, Me, etc.; R12 is H, halo, C1-4 alkyl, etc.; R13 is H, halo, Me and OMe;) and salts, solvates thereof and derivatives thereof, their preparation and use as CTR synthase 1 inhibitors for the treatment of disorders associated with cell proliferation. Example compound II was prepared by cross-coupling of N-(4-bromophenyl)-2-(2-(cyclopropanesulfonamido)thiazol-4-yl)-2-methylpropanamide with pyrimidin-5-ylboronic acid. The invention compounds were evaluated for their CTRS1 inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of ≤ 1μM. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to sulfonamidothiazole preparation ctrs1 inhibitor treatment cell proliferation and other aspects.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica