On February 15, 2007, Srinivas, Akella Satya Surya Visweswara; Mathiyazhagan, Kasinathan; Sharada, Duddu Savaraiah; Ponpandian, Thanasekaran; Revathy, Kulasekharan; Reddy, Gaddam Om; Kamaraj, Mani; Rajagopal, Sriram published a patent.Name: Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of heterocyclic compounds as inhibitors of histone deacetylase for treatment of cancer. And the patent contained the following:
The title heterocyclic compounds with general formula of A-(CH2)m-O-C(=X)-NH-(CH2)n-E-(CH2)p-C(=Y)-N(R1)R2 [wherein A and E = independently (hetero)aryl, arylalkyl, or benzo-fused heteroaryl, etc.; X and Y = independently O, S, or (un)substituted NH; R1 and R2 = independently H, OH, alkoxy, arylalkyl, etc.; or R1 and R2 form a ring; m, n, and p = independently 0-2], or derivatives, analogs, stereoisomers, and pharmaceutically acceptable salts thereof were prepared as inhibitors of histone deacetylase (HDAC) for treatment of cancer. For example, I was prepared in a multi-step synthesis. I showed inhibitory activity with IC50 of 0.021 μM against HDAC. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Name: Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to preparation heterocyclic compound thiazole inhibitor histone deacetylase treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Name: Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica