On February 11, 2009, Zhang, Xuebo; Yin, Peng; Liu, Gang; Xu, Lichen published a patent.Application of 64987-16-2 The title of the patent was Process for preparation of 2-[2-[[(phenylmethoxy)carbonyl]amino]thiazol-4-yl]acetic acid esters. And the patent contained the following:
The method comprises allowing to react alc. with benzyl chloroformate and base in the presence of 4-dimethylaminopyridine as catalyst at -10-0°C for 1-2 h, heating to 0-15°C, allowing to react for 4-10 h, filtrating, adding 2-(2-amino-thiazol-4-yl)acetic acid ester, further reacting for 12-24 h to obtain 2-[2-[[(phenylmethoxy)carbonyl]amino]thiazol-4-yl]acetic acid ester. The alc. is methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol and/or tert-butanol. The base is triethylamine, pyridine and/or sodium carbonate. The inventive method has advantages of short reaction route, low cost, simple operation, less three waste and suitability for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application of 64987-16-2
The Article related to phenylmethoxycarbonylamino thiazolyl acetic acid ester preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application of 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica