On May 5, 2021, Chen, Jin-Ping; Battini, Narsaiah; Ansari, Mohammad Fawad; Zhou, Cheng-He published an article.Application of 24295-03-2 The title of the article was Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. And the article contained the following:
A novel class of 7-thiazoxime quinolones was developed as potential antimicrobial agents for the sake of bypassing resistance of quinolones. Biol. assays revealed that some constructed 7-thiazoxime quinolones possessed effective antibacterial efficiency. Me acetate oxime derivative I exhibited 32-fold more active than ciprofloxacin against MRSA, which also possessed rapidly bactericidal ability and low toxicity towards mammalian cells. The combination use of 7-thiazoxime quinolone I and ciprofloxacin was able to improve antibacterial potency and effectively alleviate bacterial resistance. The preliminarily mechanism exploration revealed that compound I could destroy the cell membrane and insert into MRSA DNA to bind with DNA gyrase, then decrease the expression of gyrB and femB genes. The above results strongly suggested that Me acetate oxime derivative I held a promise for combating MRSA infection. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application of 24295-03-2
The Article related to membrane active thiazoxime quinolone preparation mrsa antibacterial dna binding, cell membrane, drug-resistance, gene, mrsa dna, quinolone, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Application of 24295-03-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica