On November 30, 2019, Joshi, Shrinivas D.; Kumar, S. R. Prem; Patil, Sonali; Vijayakumar, M.; Kulkarni, Venkatarao H.; Nadagouda, Mallikarjuna N.; Badiger, Aravind M.; Lherbet, Christian; Aminabhavi, Tejraj M. published an article.COA of Formula: C9H8N2S The title of the article was Chemical synthesis, molecular modeling and pharmacophore mapping of new pyrrole derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth. And the article contained the following:
Abstract: Substituted phenylthiazolyl benzamide and pyrrolyl benzamide derivatives were developed using mol. hybridization technique to create novel lead antimycobacterial mols. used to fight against Mycobacteriumtuberculosis. The newly synthesized mols. have inhibited InhA, the enoyl-ACP reductase enzyme from the mycobacterial type II fatty acid biosynthetic pathway. Of these, compound 3b showed H-bonding interactions with Tyr158 and co-factor NAD+ that binds the active site of InhA. All the mols. were screened for in vitro antitubercular activity against M. tuberculosis H37Rv, as well as some representative mols. as the inhibitors of InhA. Thirteen compounds exhibited good anti-TB activities (MIC = 1.6μg/mL), but only few representative mols. showed the moderate InhA enzyme inhibition activity. [Figure not available: see fulltext.]. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).COA of Formula: C9H8N2S
The Article related to pyrrole inhibitor enoylacp reductase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.COA of Formula: C9H8N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica