On May 26, 1983, Kinast, Guenther published a patent.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Intermediates useful in the preparation of cephalosporins. And the patent contained the following:
Thiazolines I [R = protective group; R1, R2 = (un)substituted alkyl, cycloalkyl, aryl, heterocyclic], useful as intermediates for cephalosporins II [R3 = (un)substituted alkyl, cycloalkyl, aryl, heterocyclic; R4 = appropriate substituent], were prepared Thus Et 2-amino-4-thiazolylacetate was treated with (Me3CO2C)2O to give I (R = Me3CO2C, R1 = CMe3, R2 = Et) which was treated with MeCHO to give III. Saponification of III to the acid, successive reaction with MeSO2Cl and 7-aminocephalosporanic acid, and deblocking gave II (R3 = Me, R4 = CH2OAc). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Safety of Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to aminothiazolylalkenamidocephem, cephem aminothiazolylalkenamido, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica