On January 18, 2007, Lau, Jesper; Murray, Anthony; Vedsoe, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.Category: thiazole The title of the patent was Preparation of cyclohexyl thiazolyl ureas as glucokinase activators. And the patent contained the following:
Title compounds represented by the formula R1R2NCONHA [wherein R1 = (cycloalkyl)alkyl, cycloalkyl, heterocyclyl, etc.; R2 = (cyclo)alkyl, cycloalkenyl, heterocyclyl, etc.; A = (un)substituted heteroaryl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reductive condensation of phenethylamine with cyclohexanone, followed by coupling reaction with Et (2-aminothiazol-5-ylsulfanyl)acetate in the presence of 1,1′-carbonyldiimidazole and hydrolysis, gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of various diseases, e.g. for the treatment of type 2 diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Category: thiazole
The Article related to cyclohexyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica