On December 12, 2017, Liu, Denggui; Yang, Kunyu; Zhou, Wei; Chen, Hao; Zeng, Qingdong published a patent.Application In Synthesis of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate The title of the patent was Method for preparing anticancer drug intermediate. And the patent contained the following:
The title anticancer drug intermediate is a compound shown in formula IIIa or IIIb. The title method comprises the steps of: conducting halogenation on 2-acetyl-4-formate thiazole compound, and reacting with tri-Ph phosphine, tri-Me phosphite, or tri-Et phosphite. The inventive compound can be applied in preparing a compound shown in formula I via conducting Wittig or Wittig-Horner reaction with isobutyraldehyde. The preparing process has the advantages of low raw material costs, mild reaction conditions, little pollution, and easy industrialization. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Application In Synthesis of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate
The Article related to thiazole containing phosponate preparation anticancer drug intermediate, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Application In Synthesis of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica