On July 21, 2005, Murray, Anthony; Lau, Jesper; Jeppesen, Lone; Vedso, Per; Ankersen, Michael; Lundbeck, Jane Marie; Kristiansen, Marit; Valcarce-Lopez, Maria Carmen; Polisetti, Dharma Rao; Subramanian, Govindan; Andrews, Robert Carl; Christen, Daniel P.; Cooper, Jeremy T.; Santhosh, Kalpathy Chidambareswaran published a patent.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Preparation of heteroaryl ureas and their use as glucokinase activators. And the patent contained the following:
Title compounds I [wherein R1, R2 = (un)substituted cycloalk(en)yl, heterocyclyl or heterocycloalkenyl; A = (un)substituted heteroaryl, or pharmaceutically acceptable salts, stereoisomers and tautomers thereof] were prepared For example, treatment of 2-aminothiazole with carbonyldiimidazole followed by condensation with dicyclohexylamine gave urea II. The invented compounds are activators of glucokinase, and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate
The Article related to urea heteroaryl preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica