On November 8, 2007, Murray, Anthony; Lau, Jesper; Jeppesen, Lone; Vedsoe, Per published a patent.Related Products of 859522-19-3 The title of the patent was Preparation of thiazolyl benzamides as glucokinase activators. And the patent contained the following:
Title compounds [I; m = 0-2; n = 0-4; R1 = OH, hydroxyalkyl, fluoroalkyl, Cll, F, Br, iodo, alkyl, alkenyl, alkynyl, amino, cyano, Ph, (substituted) heterocyclyl, etc.; R2 = YX; X = OZ, OZOZ, CO2Z, SZ, SOZ, SO2Z, etc.; Z, Z1 = bond, alkenylene, etc.; Y = (substituted) QZ1, etc.; Q = aryl, heterocyclyl, cycloalkyl; B = substituted 5-10 membered heterocyclyl], were prepared as glucokinase activators (no data). Thus, title compound Me [2-(3-isopropoxy-5-phenoxybenzoylamino)thiaol-5-ylsulfanyl]acetate was prepared in 4 steps from Me 3-isopropoxy-5-hydroxybenzoate, phenylboronic acid, 5-bromo-2-aminothiazole, 3-isopropoxy-5-phenoxybenzoic acid, and Me mercaptoacetate. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Related Products of 859522-19-3
The Article related to thiazolyl benzamide preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 859522-19-3
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica