Day: November 3, 2022

On January 31, 2014, Praveen, Aletti S.; Yathirajan, Hemmige S.; Narayana, Badiadka; Sarojini, Balladka K. published an article.Name: Methyl 2-(2-aminothiazol-4-yl)acetate The title of the article was Synthesis, characterization and antimicrobial studies of a few novel thiazole derivatives. And the article contained the following:

A series of novel N-[4-(substituted)-1,3-thiazol-2-yl]-2-(substituted)acetamides and Me 2-(2-(2-(substituted)acetamido)thiazol-4-yl)acetates were synthesized. All compounds were screened for their in vitro antibacterial activity against S. aureus, E. coli, P. aeruginosa, and K. pneumonia by disk diffusion and for antifungal activity against P. marneffei, T. mentagrophytes, A. flavus, and A. fumigatus by serial plate dilution Some of the compounds exhibited growth inhibition against all the tested bacterial strains, with MIC of 12.5-6.25 μg/mL. Among the compounds tested for antifungal activity, several of them showed a wide range of activity against all the tested strains. Most of the newly synthesized compounds were effective against fungal strains rather than bacterial strains. However, some of the compounds showed selective sensitivity against some of the bacterial strains, whereas they were unable to sustain the growth of other strains. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Name: Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to thiazole amide preparation antibacterial antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Name: Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 26, 1986, Onoue, Hiroshi; Takahashi, Hiromi published a patent.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Thiazolylpentenedioic acids. And the patent contained the following:

Esters I (R1 = NH2, protected amino; R2 = standard alc. residue; R3 = H, cyano, esterified CO2H; R4 = H, cyano, esterified CO2H) were prepared Thiazoleacetate ester II was treated with MeOCH:C(CO2Me)2; the product underwent elimination reaction to yield I (R1 = NHCO2CH2Ph, R2 = Me, R3 = R4 = CO2H), and the latter was subjected to hydrolysis-decarboxylation to give I (R1 = NHCO2CH2Ph, R2 = R3 = H, R4 = CO2H). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to thiazolylpentenedioic acid, glutaconic acid thiazolyl, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 8, 2007, Murray, Anthony; Lau, Jesper; Jeppesen, Lone; Vedsoe, Per published a patent.Related Products of 859522-19-3 The title of the patent was Preparation of thiazolyl benzamides as glucokinase activators. And the patent contained the following:

Title compounds [I; m = 0-2; n = 0-4; R1 = OH, hydroxyalkyl, fluoroalkyl, Cll, F, Br, iodo, alkyl, alkenyl, alkynyl, amino, cyano, Ph, (substituted) heterocyclyl, etc.; R2 = YX; X = OZ, OZOZ, CO2Z, SZ, SOZ, SO2Z, etc.; Z, Z1 = bond, alkenylene, etc.; Y = (substituted) QZ1, etc.; Q = aryl, heterocyclyl, cycloalkyl; B = substituted 5-10 membered heterocyclyl], were prepared as glucokinase activators (no data). Thus, title compound Me [2-(3-isopropoxy-5-phenoxybenzoylamino)thiaol-5-ylsulfanyl]acetate was prepared in 4 steps from Me 3-isopropoxy-5-hydroxybenzoate, phenylboronic acid, 5-bromo-2-aminothiazole, 3-isopropoxy-5-phenoxybenzoic acid, and Me mercaptoacetate. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Related Products of 859522-19-3

The Article related to thiazolyl benzamide preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 859522-19-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 18, 2007, Lau, Jesper; Murray, Anthony; Vedsoe, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.Category: thiazole The title of the patent was Preparation of cyclohexyl thiazolyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula R1R2NCONHA [wherein R1 = (cycloalkyl)alkyl, cycloalkyl, heterocyclyl, etc.; R2 = (cyclo)alkyl, cycloalkenyl, heterocyclyl, etc.; A = (un)substituted heteroaryl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reductive condensation of phenethylamine with cyclohexanone, followed by coupling reaction with Et (2-aminothiazol-5-ylsulfanyl)acetate in the presence of 1,1′-carbonyldiimidazole and hydrolysis, gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of various diseases, e.g. for the treatment of type 2 diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Category: thiazole

The Article related to cyclohexyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 18, 2007, Murray, Anthony; Lau, Jesper; Vedsoe, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.Related Products of 859522-19-3 The title of the patent was Preparation of dicycloalkyl thiazolyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula R1R2NCONHA [wherein R1 = (un)substituted cyclohexyl; R2 = cyclohexyl; A = (un)substituted thiazolyl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reaction of 2-aminothiazole with dicyclopentylamine and carbonyldiimidazole gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Related Products of 859522-19-3

The Article related to dicycloalkyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 859522-19-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 1, 2009, Murray, Anthony; Lau, Jesper; Vedso, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.SDS of cas: 859522-19-3 The title of the patent was Preparation of dicycloalkyl thiazolyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula R1R2NCONHA [wherein R1 = (un)substituted cyclohexyl; R2 = cyclohexyl; A = (un)substituted thiazolyl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reaction of 2-aminothiazole with dicyclopentylamine and carbonyldiimidazole gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of various diseases such as diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).SDS of cas: 859522-19-3

The Article related to dicycloalkyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 859522-19-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica