On May 31, 2007, Sani, Monica; Fossati, Giacomo; Huguenot, Florent; Zanda, Matteo published an article.Reference of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate The title of the article was Total synthesis of tubulysins U and V. And the article contained the following:
A reliable and modular reaction sequence has been developed for the synthesis of the challenging tubulysin U and V (I, R = OAc, OH). This route allowed preparation of hundreds of milligrams of the stereochem. pure tetra-peptides, which are produced in small amounts by two different species of myxobacteria. This strategy made the full biol. evaluation of the tubulysins and their analogs possible. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Reference of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate
The Article related to tubulysin asym preparation, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Reference of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica