On May 21, 2008, Zhao, Hongfu; Liu, Gang; Zheng, Gengxiu; Sun, Bin; Guo, Fangshui; Wang, Guangzheng published a patent.Electric Literature of 64987-16-2 The title of the patent was Method for preparing 2-(2-butoxycarbonylaminothiazol-4-yl)-2-pentenoate. And the patent contained the following:
The title method comprises: (1) carrying out reaction of alkyl 2-(2-aminothiazol-4-yl)acetate 1.0 mol and di-tert-Bu dicarbonate 1.0-1.5 mol in the presence of 4-N,N-dimethylaminopyridine as catalyst at 0-80°C to obtain alkyl 2-(2-butoxycarbonylaminothiazol-4-yl)acetate, and (2) cooling alkyl 2-(2-butoxycarbonylaminothiazol-4-yl)acetate to -60-0°C, adding alkali, adding propionaldehyde, heating to room temperature, and carrying out reaction to obtain the final product. The method has the advantages of shortening reaction time, reducing usage of di-tert-Bu dicarbonate, and enhancing yield. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Electric Literature of 64987-16-2
The Article related to aminothiazolylpentenoate butoxycarbonyl preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica