Day: November 4, 2022

Du, Wenbin; Zhao, Mengyao; Zhen, Dawei; Tan, Jia; Wang, Tianze; Xie, Jianchun published an article in 2020, the title of the article was Key aroma compounds in Chinese fried food of youtiao.Application In Synthesis of 2-Acetylthiazole And the article contains the following content:

Key aroma compounds in Chinese popular fried food of youtiao were characterized by solvent assisted flavor evaporation combined with gas chromatog.-mass spectrometry (GC-MS) and aroma extract dilution anal. of gas chromatog.-olfactometry (AEDA/GC-O), quantitation, and aroma recombination and omission. Four samples of youtiao fried with sunflower oil, soybean oil, rapeseed oil, and palm oil, resp., differing in fatty acid composition, were selected to be investigated. A total of thirty-five odorants were identified, among which twenty-two odorants were quantitated by aid of authentic chems. and with correction of recovery coefficients Differences in odorants composition and aroma profile were observed among the four samples of youtiao fried with different oils. However, it was demonstrated in common thirteen compounds; i.e., 3-hydroxy-2-butanone, 3-methylbutanal, furfural, 3-(methylthio)propanal, 2-furfurylthiol, phenylacetaldehyde, 2,5-dimethyl-4-hydroxy-3(2H)-furanone, 2-ethyl-3,5-dimethylpyrazine, 3-ethyl-2,5-dimethylpyrazine, (E,E)-2,4-decadienal, 1-octen-3-ol, (E,Z)-2,6-nonadienal, and (E)-2-nonenal contributed significantly to youtiao aroma. The work can provide some guidance to maintain the preferred youtiao flavor when modifying its preparation technol. for safety concerns. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to youtiao aroma compound chinese fried food, Food and Feed Chemistry: Fats, Oils, and Margarine and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 26, 2015, Lin, Songnian; Parmee, Emma R.; Xu, Jiayi published a patent.Application In Synthesis of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Novel 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment. And the patent contained the following:

Novel pyridine-2-carboxamide derivatives of formula I and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included. The present invention relates to novel pyridine-2-carboxamide derivatives and salts thereof which are effective as glucokinase activating agents. Moreover, it relates to compositions containing such compounds, and methods of treatment. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Application In Synthesis of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

The Article related to pyridinecarboxamide preparation glucokinase activator antidiabetic antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 26, 2014, Parmee, Emma R.; Xu, Jiayi published a patent.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Preparation of novel 2-pyridinecarboxamide derivatives as glucokinase activators useful in treating diseases. And the patent contained the following:

The title compounds I [R1, R2 = (un)substituted 6-10 membered aryl, 5-10 membered heteroaryl, 5-7 membered cycloalkyl, or 5-7 membered aliphatic heterocyclic group; ring A = (un)substituted 5-7 membered monocyclic or 9-10 membered bicyclic heteroaryl group in which the carbon atom attached to the amide nitrogen atom contained in formula I forms C:N together with the nitrogen atom in the ring; L = alkyl, alkoxyalkyl, alkoxy, etc.; T = CO2R, COR3R4, P(O)(OR5)2; R, R3-R5 = H or alkyl] that are effective as glucokinase activating agents, and useful for treating or preventing type 2 diabetes and similar conditions, were prepared E.g., a multi-step synthesis of II, starting from 6-chloro-3-fluoropyridine-2-carboxylic acid, was described. The GK activation capability of the exemplified compounds I was determined (data given). Pharmaceutical compositions and methods of treatment were also included. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

The Article related to pyridinecarboxamide preparation glucokinase activator antidiabetic antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 18, 1993, Lind, Peter Thomas; Morin, John Michael, Jr.; Noreen, Rolf; Ternansky, Robert John published a patent.Recommanded Product: 64987-16-2 The title of the patent was Thiourea derivatives and methods for inhibition of HIV and related viruses. And the patent contained the following:

A method for the inhibition of the replication of HIV is claimed that comprises contacting HIV with thiourea derivatives Among the specifically claimed compounds is N-[2-(2-pyridyl)ethyl]-N’-(5-bromo-2-pyridyl)thiourea (I). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Recommanded Product: 64987-16-2

The Article related to virucide hiv thiourea preparation, pyridylethyl thiourea preparation virucide hiv, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 22, 2005, Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew S.; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang; Wodka, Dariusz published a patent.Safety of Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of piperidinyl chromenecarboxamides as antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor. And the patent contained the following:

The present invention is directed to compounds of formula (I, variables defined below), which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders. The variables for I are: L = a bond or alkylene, alkenylene, alkynylene, CH2O, SO2NH, C(O)NH, NHCO, NHSO2, CO, SO and SO2; X = O and N(R13); Z = CH2, C(N-Rc), CO and CS; m = 1 or 2; n = 0-2; R1, R2 and R3 = H, alkenyl, alkoxy, alkyl, alkylcarbonyl, alkylcarbonyl-NH-, alkyl-NH-carbonyl, alkylsulfonyl-NH-, alkyl-NH-sulfonyl, alkylsulfonyl, alkylthio, alkynyl, cyano, halogen, haloalkyl, haloalkoxy, haloalkylthio, nitro, RaRbN, RaRbNC(O)- or R1 and R2 together with intervening atoms form a heteroaryl or heterocycle; R4 = H, alkyl, alkylcarbonyl-NH-, alkylsulfonyl-NH-, aryl and halogen; R5 = H and alkyl; R6 = H, alkyl, aryl, cycloalkyl, heteroaryl and heterocycle; R7 = aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle and heterocyclealkyl, or R6 and R7 together with attached atoms form a cycloalkyl or heterocycle; R8 = H, alkyl and alkoxy; R9 = H and alkyl; R10 and R11= H, alkyl, alkoxylalkyl, or R10 and R11 together with intervening atoms form a 5, 6, or 7-membered ring; R12 = H and alkyl; R13 = H, alkyl, aryl, cycloalkyl, heteroaryl and heterocycle; Ra and Rb = H, alkoxycarbonyl, alkyl, alkylcarbonyl, alkyl-NH-carbonyl, alkylsulfonyl, aryl and arylalkyl or Ra and Rb together with the attached N form a heteroaryl or heterocycle; and Rc = H and alkyl; provided that at least one of R1, R2 or R3 are not H. Pharmaceutical formulations containing I are also claimed. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Safety of Benzo[d]thiazol-6-ylmethanol

The Article related to piperidinyl chromene carboxamide preparation antagonist melanin concentration hormone antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of Benzo[d]thiazol-6-ylmethanol

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 25, 2005, Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew Stephen; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang published a patent.Name: Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of piperidinyl-chromene carboxamides as antagonists of melanin-concentrating hormone. And the patent contained the following:

Title compounds I [L = a bond, alkyl, alkenyl, etc.; W = (CH2)n; X = O or NR13; Y = (CH2)m; Z = CH2, CO, CS, etc.; m = 1-2; n = 0-2; R1, R2 and R3 independently = H, halo, alkoxy, etc.; R4 = H, aryl, alkyl-C(O)-NH-, etc.; R5 = H or alkyl; R6 = H, cycloalkyl, heterocycle, etc.; R7 = aryl, arylalkyl, heterocycloalkyl, etc.; R8 = H, alkyl or alkoxy; R9 = H or alkyl; R10 and R11 independently = H, alkyl, alkoxyalkyl, etc. or together may form 5-7 membered ring; R12 = H or alkyl; R13 = H, alkyl, aryl, etc.] and their pharmaceutically acceptable salts, are prepared and disclosed as antagonists of melanin-concentrating hormone (MCH). Thus, e.g., II was prepared by cyclization of 1-(4-chloro-2-hydroxyphenyl)ethanone (preparation given) with di-Et oxalate followed by hydrolysis and coupling with 4-amino-1-N-Boc-piperidine and subsequent deprotection and coupling with piperonal. The activity of I was evaluated in fluorescence assays following the intracellular calcium release induced by MCH and it was revealed that compounds of the invention inhibit MCH induced fluorescence at a dose of 10 μM. I as antagonists of melanin-concentration hormone should prove useful in the treatment of obesity, depression and psychiatric disorders. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Name: Benzo[d]thiazol-6-ylmethanol

The Article related to piperidinyl chromene carboxamide preparation antagonist melanin concentration hormone antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: Benzo[d]thiazol-6-ylmethanol

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2020, Ma, Rongrong; Tian, Yaoqi; Chen, Long; Jin, Zhengyu published an article.Electric Literature of 24295-03-2 The title of the article was Impact of cooling rates on the flavor of cooked rice during storage. And the article contained the following:

The results obtained from flash gas chromatog. electronic nose and sensory anal. showed that higher cooling rates prolonged rice fragrance retention, whereas faster deterioration of flavor acceptability of cooked rice was observed at lower cooling rates during storage. The contribution of 43 flavor compounds in cooked rice was validated in three parallel tests by gas chromatog.-mass spectrometry combined with principal component anal., which indicated that 2-acetyl-1-pyrroline and alcs. contributed to the fragrance, while aliphatic aldehydes (at high concentration), benzene derivatives, and acids were responsible for flavor deterioration. Partial least squares regression further identified that eight flavor compounds [(E,E)-2,4-decadienal, 2-butyl-2-octenal, 1-hexanol, 2-propyl-1-pentanol, 2-butyl-furan, geranylacetone, 2-acetylthiazole, and 2-acetyl-1-pyrroline] had significantly pos. contributions to sensory evaluations, while nine flavor compounds [hexanal, octanal, (E)-2-octenal, decanal, (E)-5-methyl-4-hepten-3-one, n-hexadecanoic acid, ethylbenzene, o-xylene and p-xylene] had significantly neg. contributions to sensory evaluations during storage (p < 0.05). The water migration and/or starch crystallization of cooked rice during storage affected by cooling rates were supposed to affect the release of the flavor compounds These findings could provide a reference for the flavor preservation of instant rice. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to cooked rice flavor storage, Food and Feed Chemistry: Cereals and Bakery Products and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 15, 2022, Jia, Jie; Xiong, Dandan; Bai, Jie; Yuan, Yirong; Song, Qi; Lan, Tian; Tian, Liangjie; Guo, Chunfeng; Liu, Xuebo; Wang, Caixia; Duan, Xiang published an article.Computed Properties of 24295-03-2 The title of the article was Investigation on flavor and physicochemical properties of angel food cakes prepared by lactic acid fermented egg white. And the article contained the following:

Our recent research revealed that moderate lactic acid fermentation endowed egg white with stronger foaming properties. This inspired us to further investigate the potential application of lactic acid fermented egg white in food system. In this paper, we systematically investigated the flavor and physicochem. properties of angel food cakes prepared by egg white fermented for different times (0, 3, 6 and 9 h). Results proved the utilization of 6 h-fermented egg white decreased the baking loss of cakes. And the flavor profiles of cakes with fermented egg white were significantly improved, resulting from the changed composition of egg white. The lightness, redness and yellowness were higher in cakes with 9 h-fermented egg white compared with control cakes. Meanwhile, the cakes with fermented egg white showed a lower volume and less resilient. These results suggested that fermented egg white could endow angel food cakes with improved aroma, and verified our previous viewpoint that lactic acid fermentation has a potential to be applied in egg products. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2

The Article related to lactic acid egg white food cake flavor physicochem property, Food and Feed Chemistry: Cereals and Bakery Products and other aspects.Computed Properties of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 30, 2021, Wang, Yuan-Hui; Yang, Yue-Ying; Zhang, Jing-Yu; Zhang, Qi-Dong; Xu, Fei; Li, Zhi-Jian published an article.Computed Properties of 24295-03-2 The title of the article was Characterization of volatiles and aroma in Chinese steamed bread during elaboration. And the article contained the following:

Effects of different process steps on volatiles and aroma compounds of “Jiaozi” steamed breads (JSBs) fermented by Jiaozi starter were investigated for finding the key process steps related to aroma formation. Thirty aroma-active compounds were identified using Gas chromatog.-mass spectrometry (GC-MS) and GC-olfactometry, which provided green, fatty, mushroom, mossy, fruity, sweaty, floral odors to JSBs. GC-MS anal. showed that the concentration of volatiles in JSB dough increased gradually during first-mixing and primary fermentation; decreased after second-mixing, kneading, molding and secondary fermentation; and increased greatly after steaming. Cluster anal. indicated that the aroma profile of fresh cooked JSBs was different from that of JSB dough. Fermentation is an important stage of aroma formation of JSBs. Furthermore, steaming is also a key process step in the formation of JSBs aroma, which endows JSBs unique aroma characteristic that is different from those produced by fermentation The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2

The Article related to bread volatiles octanol aroma kneading molding steaming china, Food and Feed Chemistry: Cereals and Bakery Products and other aspects.Computed Properties of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 1, 2010, Law, K. P. published an article.Synthetic Route of 92-36-4 The title of the article was Surface-assisted laser desorption/ionization mass spectrometry on nanostructured silicon substrates prepared by iodine-assisted etching. And the article contained the following:

Surface-assisted laser desorption/ionization (SALDI) is a matrix-free mass spectrometry (MS) approach that utilizes the unique properties of a nanostructured surface to promote desorption and ionization. However, there are still questions on what constitutes a suitable SALDI substrate for mass spectrometric application. A range of SALDI substrates prepared by anodization with an oxidizing electrolyte was investigated. The laser desorption/ionization (LDI) performance was examined on a reflectron time-of-flight (ToF) mass spectrometer. The physicochem. properties of the substrates were characterized by a number of surface anal. techniques including SEM, at. force microscopy (AFM), secondary ion mass spectrometry (SIMS), XPS and water contact angle measurement. Examination of surface cleaning technologies and methods for surface chem. modification were carried out. Correlation between the substrate physicochem. properties and the LDI performance was determined It was found that only the substrate, which had a thick nanostructured layer, was effective for LDI-MS. SALDI substrate was found to have a high surface potential. However, this unique property offered no advantage for the application of LDI-MS. Surface chem. is also an important factor in affecting the LDI performance. Plasma etching can effectively remove the surface contamination but it also increases the thickness of the oxide layer. Fluorine and hydroxyl termination is advantageous. Fluorine passivation increases the surface hydrophobicity, which confines the analyte solution droplet to a smaller area and also withdraws the electronic d. from the surface, and acidifies the surface Si-OH moieties, which is believed a major proton source. The effect of laser etching was investigated by SIMS and XPS imaging and provided new insight of the SALDI ionization mechanism. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Synthetic Route of 92-36-4

The Article related to iodine assisted etching nanostructure silicon saldi mass spectrum, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Synthetic Route of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica