Hamashima, Y. published an article in 1989, the title of the article was Synthesis, biological properties, and pharmacokinetics of 7432-S, a new oral cephem.SDS of cas: 64987-16-2 And the article contains the following content:
A number of cephems with ω-carboxyalkenoylamino substituents were prepared and tested for antibacterial activity and oral absorbability. Of these derivatives, the cephem with 7β-(2-(2-amino-4-thiazolyl)-4-carboxy-2-butenoyl)amino] substituent were well absorbed in mice. 7432-S (I) was finally selected as the clin. candidate having antibacterial activity and excellent oral bioavailability. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).SDS of cas: 64987-16-2
The Article related to cephem 7432s preparation bactericide pharmacokinetics, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.SDS of cas: 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica