On August 15, 2010, Hu, Wan-Ping; Chen, Yin-Kai; Liao, Chao-Cheng; Yu, Hsin-Su; Tsai, Yi-Min; Huang, Shu-Mei; Tsai, Feng-Yuan; Shen, Ho-Chuan; Chang, Long-Sen; Wang, Jeh-Jeng published an article.COA of Formula: C14H12N2S The title of the article was Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents. And the article contained the following:
Photodynamic therapy (PDT) employing exogenous photosensitizers is currently being approved for treatment of basal cell carcinoma (BCC). 2-(4-Aminophenyl)benzothiazoles (6) consist of chromophoric structure and absorb light in the UVA (315-400 nm). These results encouraged us to design and synthesize a diversity of 2-phenylbenzothiazoles (6). Studies on the apoptotic mechanism involved in photosensitive effects induced by UVA-activated 6 in BCC cells are carried out in the present article. 6-UVA-treated cells displayed several features of apoptosis, including an increase in the sub-G1 population, a significantly increased annexin V binding, and activation of caspase-3. 6-UVA induced a decrease in mitochondrial membrane potential (Δψ mt) and ATP via enhanced ROS generation and promoted phosphorylation of extracellular signal-regulated kinase (ERK) and p38 MAPK expression. These results suggest that 6-UVA elicits photosensitive effects in mitochondria processes which involve ERK and p38 activation, and ultimately lead to BCC cell apoptosis. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).COA of Formula: C14H12N2S
The Article related to aminophenyl benzothiazole derivative preparation pdt photosensitizer, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.COA of Formula: C14H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica