On July 20, 2007, Kim, Mi Kyoung; Choo, Il Han; Lee, Hyo Sun; Woo, Jong Inn; Chong, Youhoon published an article.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was 3D-QSAR of PET agents for imaging β-amyloid in Alzheimer’s disease. And the article contained the following:
The accumulation of excess senile plaques (β-amyloid, Aβ-plaques) in the brain is strongly associated with the pathogenesis of Alzheimer’s disease (AD). While there are no definitive treatments available to affect a cure of AD, much recent interest has been given to the development of antiamyloid therapies aimed at halting and reversing Aβ-deposition and, thus, monitoring of the therapeutic efficacy would greatly benefit from methods for the in vivo detection and quantification of Aβ-deposits in the brain. A 3D-QSAR model was constructed with several PET ligands such as Thioflavin-T analogs and stilbene derivatives using CoMFA (Comparative Mol. Field Anal.) and CoMSIA (Comparative Mol. Similarity Indexes Anal.). The 3D-QSAR model could be applied to predict binding affinity of the structurally related compounds against Aβ-plaques. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole
The Article related to beta amyloid pet imaging agent qsar model, thioflavin stilbene derivative amyloid plaque imaging qsar, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica