On August 25, 2005, Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew Stephen; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang published a patent.Name: Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of piperidinyl-chromene carboxamides as antagonists of melanin-concentrating hormone. And the patent contained the following:
Title compounds I [L = a bond, alkyl, alkenyl, etc.; W = (CH2)n; X = O or NR13; Y = (CH2)m; Z = CH2, CO, CS, etc.; m = 1-2; n = 0-2; R1, R2 and R3 independently = H, halo, alkoxy, etc.; R4 = H, aryl, alkyl-C(O)-NH-, etc.; R5 = H or alkyl; R6 = H, cycloalkyl, heterocycle, etc.; R7 = aryl, arylalkyl, heterocycloalkyl, etc.; R8 = H, alkyl or alkoxy; R9 = H or alkyl; R10 and R11 independently = H, alkyl, alkoxyalkyl, etc. or together may form 5-7 membered ring; R12 = H or alkyl; R13 = H, alkyl, aryl, etc.] and their pharmaceutically acceptable salts, are prepared and disclosed as antagonists of melanin-concentrating hormone (MCH). Thus, e.g., II was prepared by cyclization of 1-(4-chloro-2-hydroxyphenyl)ethanone (preparation given) with di-Et oxalate followed by hydrolysis and coupling with 4-amino-1-N-Boc-piperidine and subsequent deprotection and coupling with piperonal. The activity of I was evaluated in fluorescence assays following the intracellular calcium release induced by MCH and it was revealed that compounds of the invention inhibit MCH induced fluorescence at a dose of 10 μM. I as antagonists of melanin-concentration hormone should prove useful in the treatment of obesity, depression and psychiatric disorders. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Name: Benzo[d]thiazol-6-ylmethanol
The Article related to piperidinyl chromene carboxamide preparation antagonist melanin concentration hormone antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: Benzo[d]thiazol-6-ylmethanol
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica