Day: November 4, 2022

On November 15, 2021, Johnson, Jino; Yardily, A. published an article.Name: 2-Acetylthiazole The title of the article was Spectral, modeling and biological studies on a novel (E)-3-(3-bromo-4-methoxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one and some bivalent metal(II) complexes. And the article contained the following:

A thiazole-based chalcone ligand (E)-3-(3-bromo-4-methoxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one (BMTP) and its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized. The synthesized compounds were characterized by elemental analyses, FT-IR, NMR, mass, molar conductance, UV-Vis, magnetic susceptibility, and thermal techniques. The title compounds were optimized with D. Functional Theory (DFT) computations. The Lewis base character of BMTP, flexibility towards metal ions, structural stabilization on coordination, MO interactions, quantum chem. descriptors, and vibrational frequencies were evaluated. The compounds were screened for antimicrobial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Aspergillus flavus and Candida albicans. Metal complexes exhibit higher microbial toxicity than the free ligand. The mol. docking interactions were found to be in good agreement with the exptl. microbial activities. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to transition metal bromomethoxyphenylthiazolylpropenone complex preparation bactericide, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2022, Darmanovic, Darinka; Radanovic, Dusanka; Jevtovic, Mima; Turel, Iztok; Pevec, Andrej; Milcic, Milos; Gruden, Maja; Zlatar, Matija; Djordjevic, Natasa; Andjelkovic, Katarina; Cobeljic, Bozidar published an article.Application In Synthesis of 2-Acetylthiazole The title of the article was Coordination preferences of NNO and NNS Schiff base ligands with Co(III) complexes: Synthesis, characterization and DFT calculation. And the article contained the following:

Two Co(III) complexes with condensation product of thiosemicarbazide and 2-acetylthiazole (HL1 ligand, (E)-2-(1-(thiazol-2-yl)ethylidene)hydrazine-1-carbothioamide) and the condensation product of 2-acetylpyridine and Girard’s P reagent (HL2Cl ligand, (E)-1-(2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethyl)pyridin-1-ium chloride) have been synthesized and characterized based on the results of single-crystal X-ray diffraction, NMR and IR spectroscopy and elemental anal. Cobalt(III) complex with HL1 ligand, [Co(L1)2]BF4·H2O (1), is bis octahedral complex in which two deprotonated ligand mols. coordinate in a mer arrangement through two NNS sets of donor atoms. In cobalt(III) complex with HL2Cl, [Co(L2)(N3)3] (2), the ligand is coordinated in deprotonated, formally neutral, form to Co(III) ion in tridentate fashion through NNO set of donor atoms, and the other three coordination sites of a monokis octahedron are occupied by meridionally coordinated azide anions. DFT calculations were performed to elucidate coordination preferences of these ligands toward Co(III) ion. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to cobalt schiff base complex preparation dft, crystal structure cobalt schiff base complex, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 14, 2009, Elleder, Daniel; Young, John A. T.; Baiga, Thomas J.; Noel, Joseph P. published a patent.Related Products of 64987-16-2 The title of the patent was Non-nucleoside reverse transcriptase inhibitors. And the patent contained the following:

Disclosed herein are antiviral agents, in particular non-nucleoside reverse transcriptase inhibitors (NNRTIs). Also disclosed are methods of making the NNRTIs, as well as compositions that include such NNRTIs and methods of their use for treating viral infections, in particular retroviral infections, such as HIV infection. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Related Products of 64987-16-2

The Article related to nonnucleoside reverse transcriptase inhibitor viral infection treatment, hiv infection treatment nonnucleoside reverse transcriptase inhibitor, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Related Products of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 24, 2015, Sheik, Daniel A.; Brooks, Lauren; Frantzen, Kristen; Dewhurst, Stephen; Yang, Jerry published an article.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Inhibition of the Enhancement of Infection of Human Immunodeficiency Virus by Semen-Derived Enhancer of Virus Infection Using Amyloid-Targeting Polymeric Nanoparticles. And the article contained the following:

The semen-derived enhancer of virus infection (SEVI) is a natural amyloid material that has been shown to substantially increase viral attachment and infectivity of HIV in cells. The authors previously reported that synthetic monomeric and oligomeric amyloid-targeting mols. could form protein-resistive coatings on SEVI and inhibit SEVI- and semen-mediated enhancement of HIV infectivity. While oligomeric amyloid-binding compounds showed substantial improvement in apparent binding to SEVI compared to monomeric compounds, the authors observed only a modest correlation between apparent binding to SEVI and activity for reducing SEVI-mediated HIV infection. Here, the authors synthesized amyloid-binding polyacrylate-based polymers and polymeric nanoparticles of comparable size to HIV virus particles (∼150 nm) to assess the effect of sterics on the inhibition of SEVI-mediated enhancement of HIV infectivity. The authors show that these polymeric materials exhibit excellent capability to reduce SEVI-mediated enhancement of HIV infection, with the nanoparticles exhibiting the greatest activity (IC50 value of ∼4 μg/mL, or 59 nM based on polymer) of any SEVI-neutralizing agent reported to date. The results support that the improved activity of these nanomaterials is likely due to their increased size (diameters = 80-200 nm) compared to amyloid-targeting small mols. and that steric interactions may play as important a role as binding affinity in inhibiting viral infection mediated by SEVI amyloids. In contrast to the previously reported SEVI-neutralizing, amyloid-targeting mols. (which required concentrations at least 100-fold above the Kd to observe activity), the approx. 1:1 ratio of apparent Kd to IC50 for activity of these polymeric materials suggests the majority of polymer mols. that are bound to SEVI contribute to the inhibition of HIV infectivity enhanced by SEVI. Such size-related effects on phys. inhibition of protein-protein interactions may open further opportunities for the use of targeted nanomaterials in disease intervention. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to hiv infection sevi amyloid targeting polyacrylate nanoparticle preparation antiaids, hiv, sevi, acrylate, nanoparticles, polymer, steric inhibition, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Simic, Dejan; Zaric, Milan; Nikolic, Ivana; Zivkovic-Zaric, Radica; Canovic, Petar; Kocovic, Aleksandar; Radojevic, Ivana; Rakovic, Ivana; Jovicic Milic, Sandra; Petrovic, Djordje; Stojkovic, Danijela; Vukovic, Nenad; Kacaniova, Miroslava; Vukic, Milena; Jevtic, Verica published an article in 2022, the title of the article was Newly synthesized palladium(II) complexes with aminothiazole derivatives: in vitro study of antimicrobial activity and antitumor activity on the human prostate cancer cell line.SDS of cas: 2010-06-2 And the article contains the following content:

Five new complexes of the palladium(II) ion (C1-C5) having the general formula [(PdL2)]Cl2 with some 2-aminothiazoles (L1-L5), where L1 = 2-amino-4-(3,4-difluorophenyl)thiazole, L2 = 2-amino-5-methyl-4-phenylthiazole, L3 = 2-amino-4-phenylthiazole, L4 = 2-amino-4-(4-chlorophenyl)thiazole, and L5 = 2-amino-4-(2,4-difluorophenyl)thiazole, were synthesized and characterized by elemental microanal. and IR, 1H NMR and 13C NMR spectroscopy. The in vitro antimicrobial activity of the five ligands and the corresponding Pd(II) complexes was studied. Testing was performed by the microdilution method and the min. inhibitory concentration (MIC) and min. microbicidal concentration (MMC) were determined Testing is conducted against 11 microorganisms (nine strains of pathogenic bacteria and two yeast species). The tested ligands and palladium(II) complexes show selective, high and moderate activity. There is a difference in antimicrobial activity between the ligands and the corresponding palladium(II) complexes. The complexes have significant anti-staphylococcal activity and activity on Pseudomonas aeruginosa which is better than the pos. control. The interactions of newly synthesized palladium(II) complexes with calf thymus DNA (CT-DNA) were studied using UV-visible absorption and fluorescence spectroscopy. Anal. of UV-absorption and fluorescence spectra indicates the formation of a complex between the palladium(II) complexes and DNA. The high values of intrinsic binding constants, Kb, of the order 104 M-1 and Stern-Volmer quenching constants, KSV, of the order 105 M-1 indicated very good binding of all complexes to CT-DNA. Also, the new Pd(II) complexes show high cytotoxic activity towards the human prostate cancer cell line and insignificant activity towards non-cancerous human fibroblasts. Future research could addnl. explore the biol. activity of Pd(II) complexes presented in this paper and study the possibility of their implementation in clin. practice. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2

The Article related to palladium aminothiazole derivative complex preparation antimicrobial antitumor activity, dna interaction palladium aminothiazole derivative complex, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.SDS of cas: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 1, 2020, Goya-Jorge, Elizabeth; Abdmouleh, Fatma; Carpio, Laureano E.; Giner, Rosa M.; Sylla-Iyarreta Veitia, Maite published an article.Computed Properties of 92-36-4 The title of the article was Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities. And the article contained the following:

Benzothiazole is a privileged scaffold in medicinal chem. present in diverse bioactive compounds with multiple pharmacol. applications such as analgesic, anticonvulsant, antidiabetic, anti-inflammatory, anticancer and radioactive amyloidal imagining agents. We reported in this work the study of sixteen functionalized 2-aryl and 2-pyridinylbenzothiazoles as antimicrobial agents and as aryl hydrocarbon receptor (AhR) modulators. The antimicrobial activity against Gram-pos. (S. aureus and M. luteus) and Gram-neg. (P. aeruginosa, S. enterica and E. coli) pathogens yielded MIC ranging from 3.13 to 50μg/mL and against the yeast C. albicans, the benzothiazoles displayed MIC from 12.5 to 100μg/mL. All compounds showed promising antibiofilm activity against S. aureus and P. aeruginosa. The arylbenzothiazole 12 displayed the greatest biofilm eradication in S. aureus (74%) subsequently verified by fluorescence microscopy. The ability of benzothiazoles to modulate AhR expression was evaluated in a cell-based reporter gene assay. Six benzothiazoles (7, 8-10, 12, 13) induced a significant AhR-mediated transcription and interestingly compound 12 was also the strongest AhR-agonist identified. Structure-activity relationships are suggested herein for the AhR-agonism and antibiofilm activities. Furthermore, in silico predictions revealed a good ADMET profile and druglikeness for the arylbenzothiazole 12 as well as binding similarities to AhR compared with the endogenous agonist FICZ. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Computed Properties of 92-36-4

The Article related to aryl pyridinylbenzothiazole hydrocarbon receptor antimicrobial agonistic activity, agonism, ah receptor, antibacterial, antibiofilm, antifungal, benzothiazole, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Computed Properties of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica