On June 26, 2014, Parmee, Emma R.; Xu, Jiayi published a patent.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Preparation of novel 2-pyridinecarboxamide derivatives as glucokinase activators useful in treating diseases. And the patent contained the following:
The title compounds I [R1, R2 = (un)substituted 6-10 membered aryl, 5-10 membered heteroaryl, 5-7 membered cycloalkyl, or 5-7 membered aliphatic heterocyclic group; ring A = (un)substituted 5-7 membered monocyclic or 9-10 membered bicyclic heteroaryl group in which the carbon atom attached to the amide nitrogen atom contained in formula I forms C:N together with the nitrogen atom in the ring; L = alkyl, alkoxyalkyl, alkoxy, etc.; T = CO2R, COR3R4, P(O)(OR5)2; R, R3-R5 = H or alkyl] that are effective as glucokinase activating agents, and useful for treating or preventing type 2 diabetes and similar conditions, were prepared E.g., a multi-step synthesis of II, starting from 6-chloro-3-fluoropyridine-2-carboxylic acid, was described. The GK activation capability of the exemplified compounds I was determined (data given). Pharmaceutical compositions and methods of treatment were also included. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate
The Article related to pyridinecarboxamide preparation glucokinase activator antidiabetic antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica