Day: November 7, 2022

On September 5, 2021, El-Nahass, Marwa N. published an article.Electric Literature of 24295-03-2 The title of the article was D-π-A chalcone analogue as metal ions selective turn-on-off-on fluorescent chemosensor with cellular imaging and corrosion protection. And the article contained the following:

Novel naked eye optical chemosensor containing thiazole ring, namely; (2E,4E)-5-(4-(dimethylylamino)phenyl)-1-(thiazol-2-yl)penta-2,4-dien-1-one, DMAPTP was developed. The solvatochromic response was explored in different solvents of various polarities. The dipole moments in the ground (μg) and excited (μe) states were determined The large excited state dipole moment demonstrates the excited state′s stability in polar solvents. In an ethanolic solution, the sensing response and selectivity of the investigated chemosensor to various metal ions such as Na+, K+, Ca2+, Ba2+, Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Al3+, Hg2+, and Pb2+ were evaluated. The spectral changes suggest that DMAPTP is strongly complexed with the metal ions used. The ground and excited state binding constants, as well as the quenching constants, have been determined The mechanism of fluorescence quenching was identified as static quenching due to the formation of a non-fluorescent ground state complex using the Stern-Volmer plot. DMAPTP can also be used as a powerful chemosensor, identifying all of the metal ions studied with high sensitivity and selectivity for Fe3+ ions. DMAPTP can serve as a Turn-on-off-on chemosensor, as well as a metallochromic predictor in complexometric titration This is indicated by the ability of EDTA to decompose the formed complex with the formation of the stable metal-EDTA complex, which leads to fluorescence recovery. The anal. parameters, such as selectivity, sensitivity, and detection limit, were chosen. The fluorescence imaging experiments in living cells demonstrated the biol. chemosensing applications of DMAPTP to Fe3+ ions. Furthermore, weight loss, potentiodynamic polarization, electrochem. impedance spectroscopy, and SEM techniques were used to investigate DMAPTP as a corrosion inhibitor for carbon steel in 1.0 M HCl. The collected data reveal that as DMAPTP concentrations increased, its inhibition performance increased as well. On the basis of strong adsorption of inhibitor mols. on the surface of carbon steel and the formation of large protection films, the inhibition efficiencies were determined The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to chalcone analog metal fluorescent chemosensor cellular imaging corrosion protection, Placeholder for records without volume info and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Aslam, Sana; Xi, Yun; Ahmad, Matloob; Mansha, Asim; Farooq, Tahir; Zheng, Zongheng; Saddique, Furqan Ahmad; Wang, Fang; Fu, Liwu published an article in 2020, the title of the article was Anticancer activity of structural hybrids of various 5/6-memberedheterocycles with pyrazolobenzothiazine 5,5-dioxide.Application In Synthesis of 2-Acetylthiazole And the article contains the following content:

Thiophene, furan, coumarin and pyrazolobenzothiazine are well familiar for their biol. activities. In this research, pyrazolobenzothiazine ring system is hybridized with various S, N & O-containing heterocycles and the resulting compounds were screened for their anticancer activity against six different cancer cell lines i.e., KB (human oral carcinoma cells), MCF-7(human breast carcinoma cells), A549 (human alveolar adenocarcinoma cells), Hep-G2 (liver carcinoma cells), SGC-7901(human gastric carcinoma cells) and S1 (human colon carcinoma cells) using MTT assay. Most of the compounds exhibited good activity against KB, S1 and A549 cancer cell lines. 5k and 5p appeared as potent inhibitors of KB cell line with IC50 values 2.78 and 4.39 μM resp., 5q was a potent inhibitor of MCF-7 (IC50 value = 13.64 μM) and 5j an excellent inhibitor of A549 cell line having IC50value of 1.03 μM. 5p and 5q were inhibitors of S1 cell line (IC50 values of 8.29 μM and 7.69 μM resp.), whereas, 5o and 5q as inhibitors of Hep-G2 cell line were discovered. A number of compounds show activity exceeding that of 5-fluoruracil in different cell assays. The most potently active compounds, 5j, 5p and 5q, exhibited selectivity in targeting cancerous cells as compared to normal human PBM cells while, 5k and 5o displayed significant toxicity in normal cells. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to human gastric liver colon carcinoma memberedheterocycle pyrazolobenzothiazine dioxide anticancer, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2020, Hooshyari, Khadijeh; Rezania, Hamidreza; Vatanpour, Vahid; Salarizadeh, Parisa; Askari, Mohammad Bagher; Beydaghi, Hossein; Enhessari, Morteza published an article.Name: 4-Phenylthiazol-2-amine The title of the article was High temperature membranes based on PBI/sulfonated polyimide and doped-perovskite nanoparticles for PEM fuel cells. And the article contained the following:

A new sulfonated aromatic diamine monomer containing nitrogen heterocycles was synthesized and employed to prepare a novel sulfonated polyimide (SPI). To develop proton exchange membranes, new nanocomposite blend membranes consist of the prepared SPI and polybenzimidazole (PBI) were fabricated with incorporation of SrCe0.9Yb0.1O3-δ (SCYb) doped-perovskite nanoparticles with a solution-casting method. The goal of this work is to study the effect of SPI and SCYb doped-perovskite nanoparticles on the important parameters of the PBI membrane specially proton conductivity and fuel cell performance. The proton conductivity and phosphoric acid doping level of the PBI-SPI-SCYb nanocomposite blend membranes improved due to an interaction of -SO3H group and thiazole rings of SPI and N-H groups of PBI in the oxygen vacancies of SCYb doped-perovskite nanoparticles. Substitution of Ce4+ by Yb3+ in the SCYb doped-perovskite nanoparticles produce oxygen vacancies and decrease the columbic repulsion between protons and pos. ions. Furthermore at highest phosphoric acid doping level of 14 mol phosphoric acid per monomer unit, the nanocomposite blend membranes displayed proton conductivity of 131 mS/cm at 180 °C and 8% relative humidity. The increase in power d. from 0.31 W/cm2 in PBI-SPI blend membranes (SPI/PBI: 25 wt%) to 0.59 W/cm2 in PBI-SPI-SCYb nanocomposite blend membranes (SPI/PBI: 25 wt% and 7 wt% of SCYb) was achieved at 0.5 V, 8% RH and 180 °C, which demonstrates that these developed nanocomposite blend membranes have a high potential to be regarded as the most promising candidates for high-temperature fuel cell with improved proton conductivity The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Name: 4-Phenylthiazol-2-amine

The Article related to polybenzimidazole sulfonated polyimide doped perovskite nanoparticle proton exchange membrane, fuel cell, Placeholder for records without volume info and other aspects.Name: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2022, Alamiery, Ahmed; Mohamad, Abu Bakar; Kadhum, Abdul Amir H.; Takriff, Mohd S. published an article.Electric Literature of 2010-06-2 The title of the article was Comparative data on corrosion protection of mild steel in HCl using two new thiazoles. And the article contained the following:

This data article includes data described in the investigation report entitled “The synergistic role of azomethine group and triazole ring at improving the anti-corrosive performance of 2-amino-4-phenylthiazole” (Alamiery et al., 2021). In this data article, a comprehensive effect of 2-Amino-4-phenyl-N-benzylidene-5-(1,2,4-triazol-1-yl)thiazole (APNT) and 2-amino-4-phenylthiazole (APT) and optimized process parameter of the inhibitor in 1 M HCl solution was presented using gravimetric techniques and D. functional theory. The presence of the inhibitors influenced the corrosion resistance of mild steel (MS). Inhibition efficiencies values of 98.1% and 94.74% were recorded as results of inhibition of the MS by the inhibiting compounds APNT and ATP resp. DFT studies observed that the presence of benzylidene to the APNT and the substitution of a triazole in the thiazole ring are adsorption sites that increase the interaction of the APNT mols. with the iron atoms on the MS surface. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to mild steel hydrogen chloride thiazole corrosion protection, corrosion, hydrochloric acid, inhibitor, mild steel, Placeholder for records without volume info and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chai, Li-Juan; Fang, Guan-Yu; Xu, Peng-Xiang; Zhang, Xiao-Juan; Lu, Zhen-Ming; Zhang, Su-Yi; Wang, Song-Tao; Shen, Cai-Hong; Shi, Jin-Song; Xu, Zheng-Hong published an article in 2021, the title of the article was Novisyntrophococcus fermenticellae gen. nov., sp. nov., isolated from an anaerobic fermentation cellar of Chinese strong-flavour baijiu.Category: thiazole And the article contains the following content:

A Gram-stain-neg., coccus-shaped, obligately anaerobic, non-motile and non-spore-forming bacterium, designated strain JN500902T, was isolated from the mud in a fermentation cellar used continuously over 30 years for Chinese strong-flavor baijiu production Colonies were white, circular, convex and smooth-edged. Growth was observed at 20-40 °C (optimum, 37 °C), at pH 5.0-10 (optimum, pH 7.5), with 0-2% (w/v) NaCl and with 0-4% (volume/volume) ethanol. The Biolog assay demonstrated pos. reactions of strain JN500902T in the metabolism of l-fucose and pyruvate. The predominant cellular fatty acids (>10%) consisted of C16:0 and C14:0. The major end metabolites of strain JN500902T were acetic acid and ethanol when incubated anaerobically in liquid reinforced clostridial medium. Acetate was the major organic acid end product. The complete genome size of strain JN500902T was 3420321 bp with 3327 identified genes. The G + C content was 43.5 mol%. Phylogenetic anal. based on 16S rRNA gene sequences affiliated strain JN500902T with the family Lachnospiraceae, having low sequence similarity (92.8%) to the nearest type strain, Syntrophococcus sucromutans DSM 3224T and forming a clearly distinct branch. Core genome phylogenetic anal. of the isolate and 134 strains belonging to the family Lachnospiraceae also revealed that strain JN500902T was well-separated from other genera of this family as a monophyletic clade. The average nucleotide identity and amino acid identity values between strain JN500902T and 134 Lachnospiraceae strains were less than 74 and 65%, resp. Considering its polyphasic characteristics, strain JN500902T represents a novel genus and species within the family Lachnospiraceae, for which the name Novisyntrophococcus fermenticellae gen. nov., sp. nov. is proposed. The type strain is JN500902T (= CICC 24502T = JCM 33939T). The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to sequence novisyntrophococcus baijiu anaerobic fermentation cellar, lachnospiraceae, baijiu (chinese liquor), pit mud, Placeholder for records without volume info and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2021, Cho, Su-Hyeon; Kim, Song Rae; Jeong, Myeong Seon; Choi, Miri; Park, SeonJu; Kim, Kil-Nam published an article.Reference of 2-Acetylthiazole The title of the article was Protective Effect of Brassica napus L. Hydrosols against Inflammation Response in RAW 264.7 Cells. And the article contained the following:

To demonstrate the anti-inflammatory activity of Brassica napus L. hydrosols (BNH) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Composition anal. of BNH was conducted via gas chromatog.-mass spectrometry after BNH were extracted The nitric oxide (NO) production was measured using the Griess assay. Prostaglandin E2 (PGE2) production was evaluated with ELISA. The effects of BNH on LPS-induced pro-inflammatory enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were evaluated using Western blot anal. Furthermore, phosphorylation of nuclear factor-kappa B (NF-κB) and nuclear translocation of NF-κB p65 were evaluated with Western blot anal. and immunofluorescence staining, resp. Compared with LPS-stimulated cells, BNH markedly decreased the generation of NO and PGE2 in LPS-stimulated RAW 264.7 cells (P<0.01 or P<0.05). Moreover, BNH inhibited protein levels of iNOS and COX-2 (P<0.01). Phosphorylation of NF-κB and nuclear translocation of NF-κB p65 was significantly inhibited by BNH (P<0.01 or P<0.05). The anti-inflammatory activities of BNH were mediated via blockage of the NF-κB signaling pathways in LPS-stimulated RAW 264.7 cells. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Reference of 2-Acetylthiazole

The Article related to brassica napus hydrosols inflammation lipopolysaccharide, brassica napus l., raw 264.7 cells, hydrosols, inflammation, lipopolysaccharide, Placeholder for records without volume info and other aspects.Reference of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2019, Prashanth, T.; Avin, B. R. Vijay; Thirusangu, Prabhu; Ranganatha, V. Lakshmi; Prabhakar, B. T.; Sharath Chandra, J. N. Narendra; Khanum, Shaukath Ara published an article.Recommanded Product: 2010-06-2 The title of the article was Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma. And the article contained the following:

The synthesis and antiproliferative effect of a series of quinoline and thiazole containing coumarin analogs 12a-d and 13a-f resp., on mice leukemic cells was performed. The chem. structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral anal. The result indicates that, 7-methoxy-2-oxo-2H-chromene-3-carboxylic acid [4-(4-methoxy-phenyl)-thiazol-2-yl]-amide (13f) showed potent activity against EAC and DLA cells in MTT (15.3 μM), tryphan blue (15.6 μM) and LDH (14.2 μM) leak assay with 5-fluorouracil as a standard Further, the anti-neoplastic effect of the compound 13f was verified against Ehrlich ascites tumor by BrdU incorporation, TUNEL, FACS and DNA fragmentation assays. Exptl. data showed that compound 13f induces the apoptotic cell death by activating apoptotic factors such as caspase-8 &-3, CAD, Cleaved PARP, γ-H2AX and by degrading genomic DNA of cancer cells and thereby decreasing the ascitic tumor development in mice. Besides, compound 13f was also subjected for docking studies to approve the in vitro and in vivo studies. The data revealed that the compound 13f has very good interaction with caspase 3 protein by binding with amino acid Arg 207 through hydrogen bond. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 2010-06-2

The Article related to ascitic carcinoma coumarin analog quinoline thiazole apoptosis mol docking, antiproliferation, coumarin, in vitro, in vivo, quinoline, thiazole, Placeholder for records without volume info and other aspects.Recommanded Product: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 30, 2022, Li, Jing; Yang, Youyou; Tang, Chaohua; Yue, Shengnan; Zhao, Qingyu; Li, Fadi; Zhang, Junmin published an article.Synthetic Route of 24295-03-2 The title of the article was Changes in lipids and aroma compounds in intramuscular fat from Hu sheep. And the article contained the following:

I.m. fat (IMF) content is associated with lamb flavor and largely varies between individuals of the same breed. However, studies investigating the effects of IMF variations on lipid profiles and aroma compounds are limited. Here, we performed lipidomic and volatilomic profiling of high-IMF and low-IMF Hu lambs. Triglycerides and diglycerides in the high-IMF group were significantly higher than those in the low-IMF group (p < 0.05). Seventy-nine of 842 lipids identified were significantly different between the groups under pos. and neg. ion modes (variable importance in projection > 1, p < 0.05). Volatilomic analyses revealed that the aroma profiles also differed between the groups. Fifteen aroma compounds, mainly originating from lipid oxidation, could be responsible for this difference. Thus, our findings provide a comprehensive understanding of the increases in IMF content that drive consumers′ satisfaction and also provide a basis for underpinning breeding value for IMF. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Synthetic Route of 24295-03-2

The Article related to lipid aroma compound intramuscular fat hu sheep, intramuscular fat, lipid profile, lipidomics, odorant, partial least squares regression, volatilomics, Placeholder for records without volume info and other aspects.Synthetic Route of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2021, Al-Hamashi, Ayad A.; Koranne, Radhika; Dlamini, Samkeliso; Alqahtani, Abdulateef; Karaj, Endri; Rashid, Maisha S.; Knoff, Joseph R.; Dunworth, Matthew; Pflum, Mary Kay H.; Casero, Robert A. Jr; Perera, Lalith; Taylor, William R.; Tillekeratne, L. M. Viranga published an article.COA of Formula: C5H5NOS The title of the article was A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics. And the article contained the following:

Despite the advances in treatment strategies, cancer is still the second leading cause of death in the USA. A majority of the currently used cancer drugs have limitations in their clin. use due to poor selectivity, toxic side effects and multiple drug resistance, warranting the development of new anticancer drugs of different mechanisms of action. Here we describe the design, synthesis and initial biol. evaluation of a new class of antimitotic agents that modulate tubulin polymerization Structurally, these compounds are chalcone mimics containing a 1-(1H-imidazol-2-yl)ethan-1-one moiety, which was initially introduced to act as a metal-binding group and inhibit histone deacetylase enzymes. Although several analogs selectively inhibited purified HDAC8 with IC50 values in low micromolar range, tissue culture studies suggest that HDAC inhibition is not a major mechanism responsible for cytotoxicity. The compounds demonstrated cell growth inhibition with GI50 values of upper nanomolar to low micromolar potency with significant selectively for cancer over normal cells. Interestingly, several compounds arrested HeLaM cells in mitosis and seem to target tubulin to cause mitotic arrest. For example, when combined with inhibitors of Aurora B kinase, they led to dramatic disassembly of the mitotic spindle. In-vitro tubulin polymn studies showed that the compounds reduced the rate of polymn of microtubules during the elongation phase and lowered the amt of polymd tubulin during the plateau phase. Finally, in silico docking studies identified binding of (E)-2-(4-(3-(1H-Imidazol-2-yl)-3-oxoprop-1-en-1-yl)phenyl)-N-(4-fluorophenyl)acetamide to the colchicine site with similar affinity as the test compound D64131. These compounds represent a new antimitotic pharmacophore with limited HDAC inhibitory activity. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).COA of Formula: C5H5NOS

The Article related to chalcone mimic antitumor antimitotic tubulin disruption microtubule dynamic, anticancer agents, antimitotic agents, chalcones, mitotic arrest, mitotic spindle, Placeholder for records without volume info and other aspects.COA of Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2021, Hou, Lixia; Chen, Liyan; Song, Pinqing; Zhang, Yujin; Wang, Xuede published an article.Name: 2-Acetylthiazole The title of the article was Comparative assessment of the effect of pretreatment with microwave and roast heating on the quality of black sesame pastes. And the article contained the following:

Heating is a key procedure in producing sesame paste. The effects of microwave heating and conventional roasting on the physicochem. features, protein profiles, and volatile compounds of black sesame pastes made of black sesame seeds from Burma and China were evaluated in this study. All heating treatments decreased the moisture contents of black sesame pastes, and roasting yielded lower moisture levels, although with similar chroma (p < 0.05). The samples subjected to microwave heating had remarkably lower peroxide values than those heated with roasting (p < 0.05). Chinese microwave-heated samples had a higher nitrogen solubility index than roasting (p < 0.05). Both microwave and roasting increased the contents of the volatiles notably. SDS-PAGE showed that the intensity of the 2-15 kDa band decreased markedly after heating and nearly diminished for roasting samples, suggesting that roasting was more remarkable for the promotion to the protein aggregation. The results indicated that the quality traits of black sesame paste not only depend on the heating methods, but also the heating power/temperature and duration, and the source of the materials. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to microwave roast heating black sesame paste quality pretreatment effect, black sesame, microwave heating, physicochemical properties, roasting, volatile compounds, Placeholder for records without volume info and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica