Day: November 7, 2022

Ma, Yu-Nan; Chen, Chuan-Jiao; Li, Qing-Qing; Xu, Fu-Rong; Cheng, Yong-Xian; Dong, Xian published an article in 2019, the title of the article was Monitoring antifungal agents of Artemisia annua against Fusarium oxysporum and Fusarium solani, associated with panax notoginseng root-rot disease.Product Details of 2010-06-2 And the article contains the following content:

Root rot of Panax notoginseng has received great attention due to its threat on the plantation and sustainable utilization of P. notoginseng. To suppress the root-rot disease, natural ingredients are of great importance because of their environment friendly properties. In this study, we found that the methanol extract from Artemisia annua leaves has strong antifungal effects on the growth of Fusarium oxysporum and Fusarium solani resulting into root-rot disease. Essential oil (EO) thereof was found to be the most active. GC-MS anal. revealed 58 ingredients and camphor, camphene, β-caryophyllene, and germacrene D were identified as the major ingredients. Further antifungal assays showed that the main compounds exhibit various degrees of inhibition against all the fungi tested. In addition, synergistic effects between A. annua EO and chem. fungicides were examined Finally, in vivo experiments were conducted and disclosed that P. notoginseng root rot could be largely inhibited by the petroleum ether extract from A. annua, indicating that A. annua could be a good source for controlling P. notoginseng root-rot. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Product Details of 2010-06-2

The Article related to panax fusarium artemisia root rot disease essential oil antifungal, artemisia annua, fusarium oxysporum, fusarium solani, panax notoginseng, essential oil, root rot, Placeholder for records without volume info and other aspects.Product Details of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shaik, Shaheen; Vasa, Sreeja published an article in 2022, the title of the article was Synthesis, characterization and evaluation of semisynthetic derivatives of lawsone.Name: 4-Phenylthiazol-2-amine And the article contains the following content:

Quinones are widely distributed in nature, and several of their synthetic and natural products are very important in many diverse areas of chem. and biochem. They play a fundamental role in several living cells as electron carriers in the respiratory chain, as well as in blood coagulation and carboxylation of glutamates. Due to the intimate relationship between quinones and the biochem. processes of cells, these compounds have been extensively explored in the synthesis 2 of several bioactive compounds with antitumor, molluscicidal, antiparasitic, leishmanicidal, antiinflammatory, antifungal, antimicrobial and trypanocidal activities. In the present work we have synthesized semisynthetic derivatives of lawsone 2(a-d) by Mannich base reaction. Four derivatives of Lawson were synthesized. All the compounds synthesized were obtained in good yields. Purity of compounds was confirmed by TLC and m.ps. and compounds were characterized by preliminary laboratory techniques like chem. tests, m.p., Rf. The synthesized compounds were screened for wound healing activity. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Name: 4-Phenylthiazol-2-amine

The Article related to lawsone semisynthetic derivative synthesis, Pharmaceuticals: Formulation and Compounding and other aspects.Name: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 25, 2020, Han, Amy; Kelly, Marcus; Olson, William published a patent.Category: thiazole The title of the patent was Tubulysins and protein-tubulysin conjugates. And the patent contained the following:

Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Category: thiazole

The Article related to tubulysin protein conjugate antibody cancer, Pharmaceuticals: Formulation and Compounding and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 21, 2021, Kshirsagar, Rajendra R.; Gadekar, Pradip K.; Khedkar, Vijay M.; Vijayakumar, Vijayaparthasarathi published an article.Electric Literature of 2010-06-2 The title of the article was Design, Synthesis, and the Effects of (E)-9-Oxooctadec-10-en-12-ynoic Acid Analogues to Promote Glucose Uptake. And the article contained the following:

(E)-9-Oxooctadec-10-en-12-ynoic acid is found to mediate its antidiabetic activity by increasing insulin-stimulated glucose uptake in L6 myotubes by activating the phosphoinositide 3-kinase (PI3K) pathway. A simultaneous study of site-specific modification followed by structure-activity relationship provides a tremendous scope for exploiting the bioactivity of the parent mol. Therefore, in the present study, we focused on site-specific modification of (E)-9-oxooctadec-10-en-12-ynoic acid (1) to generate multiple derivatives and extensive structure-activity relationship (SAR) studies. We have done structural base design and synthesized a series of amides from acid compound 1. Compound 1 consists of an acid functionality, which is known for its metabolism-related liabilities. The SAR has been generated using scaffolds of different antidiabetic drugs such as biguanides, sulfonylureas, thiazolidinediones/glitazones, peroxisome proliferator-activated receptors, K + ATP, α-glucosidase inhibitors, and others. Furthermore, the study demonstrates and explains the promising derivatives and importance of SAR of the compound (E)-9-oxooctadec-10-en-12-ynoic acid. In order to gain mechanistic insights, a mol. docking study was performed against PI3K, which could identify the binding modes and thermodn. interactions governing the binding affinity. According to our research,some compounds are the best compounds from the series having EC50 values of 15.47, 8.89, 7.00, 13.99, 8.70, 12.27, and 16.14μM, resp. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to oxooctadecenynoic acid analog preparation antidiabetic activity, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 31, 2007, Ichihara, Osamu; Sampson, David; Whittaker, Mark; Bradley, Mark; Cho, Jin Ku published an article.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Development of self-indicating resin. And the article contained the following:

The development and application of self-indicating resins (SIR), materials which can indicate the presence or absence of amines in the reaction solution by the conspicuous color change of a phenolsulfophthalein type dye immobilized on resin beads has been reported. Although the functionality necessary for attaching the dye to the resins could be readily introduced by the Suzuki-Miyaura coupling during the synthesis of the SIR, this approach was only applicable to the dyes containing suitable functionality for the cross-coupling reaction. A new approach to immobilizing the indicating dyes onto the resin support is now reported. The dyes suitable for loading onto aminomethyl polystyrene (PS) resin were prepared by Friedel-Crafts reaction of 2-sulfoterephthalic anhydride with a wide range of phenols. Using this new route, polymer-supported dye I was readily prepared in >100g quantities. Use of I in the synthesis of a 144 member urea library was demonstrated and the SIR successfully indicated the endpoint of the reaction between amines and isocyanates. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to urea preparation sulfonephenolphthalein polymer supported indicator, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lin, Wei-Liang; Lin, Chung-Yin; Tai, Dar-Fu published an article in 2021, the title of the article was Preparation of a Molecularly Imprinted Film on Quartz Crystal Microbalance Chip for Determination of Furanic Compounds.Computed Properties of 24295-03-2 And the article contains the following content:

The structural preferences of furanic compounds were studied using a combination of a molecularly imprinted film (MIF) on a piezoelec.-quartz chip. The furanic compounds and their derivatives were used as the templates. Owing to their similar heterocyclic structures, it is difficult to verify the structural differences between the templates. Therefore, a new cross-linker (Methacr-l-Cys-NHBn)2, was employed to generate a platform on a quartz crystal microbalance (QCM) chip. The cross-linker self-assembled to link the surface of the chip to copolymerize with other functional monomers. A layered film with chiral hydrophobicity and rigidity was thus fabricated. Subsequently, Acr-l-Ser-NHBn was utilized as a chiral monomer to construct MIF on a QCM chip. Forcomparison, we synthesized a more hydrophobic monomer, Methacr-l-Ser-NHBn, to enhance the binding ability of the MIF. The QCM flow injection system was handled in an organic solvent system. The proportion of the monomers was adjusted to optimize the recognition ability of these films. As the binding ability of the MIF toward model templates and structurally-related furanic compounds was improved, a MIF derived from 2-furaldehyde (FUL) achieved a lower detection limit (10 ng/mL). The binding properties of MIFs prepared against furanic compounds exhibited strong similarities to the binding properties of other compounds with heterocyclic ring structures. For example, 2-furaldehyde is very similar to 2-formylthiazole, 2-acetylfuran is similar to 2-acetylthiazole, and 2-furfuryl alc. is similar to imidazole-2-methanol. Such recognition ability can help distinguish between the structural counterparts of other small heterocyclic compounds The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2

The Article related to quartz crystal chip molecularly imprinted film furanic compound determination, Organic Analytical Chemistry: Determinations and other aspects.Computed Properties of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sahni, Tanvi; Sharma, Sunita; Verma, Diksha; Kaur, Harleen; Kaur, Amanpreet published an article in 2022, the title of the article was Synthesis and in vitro Fungitoxic Evaluation of Syringaldehyde Schiff Bases and β-Lactams.Safety of 4-Phenylthiazol-2-amine And the article contains the following content:

Syringic Schiff bases I [R = Ph, Bn, 2-pyridyl, etc.] were synthesized by condensation of syringaldehyde with a number of amines, and in exploratory work two β-lactams II and III were further prepared from their progenitor 4-aminoantipyrene and 4-aminophenol imines. All the compounds were fully characterized and evaluated for their fungitoxicity against four principal phytopathogenic fungi of maize, namely R. solani, D. maydis, M. phaseolina and F. verticilloides. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Safety of 4-Phenylthiazol-2-amine

The Article related to syringaldehyde schiff base preparation antifungal, beta lactam preparation antifungal, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 22, 2011, Zanda, Matteo; Sani, Monica; Lazzari, Paolo published a patent.Recommanded Product: Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate The title of the patent was Pharmaceutical compositions comprising tubulysin compounds. And the patent contained the following:

The present invention relates to synthetic tubulysin compounds having a high cytotoxicity, with antimitotic and/or antiangiogenic properties, the corresponding solvates and pharmaceutically acceptable salts thereof, their use for the treatment of tumors and/or diseases associated to angiogenesis, and a process for their preparation with high yield. Pharmaceutical compositions comprising tubulysin compounds or their conjugates with polymers or biomols., e.g., proteins, hormones, aptamers, polysaccharides, antibodies and fragments thereof, peptides, vitamins, etc., are disclosed. Thus, (2S,4R)-4-[2-[(1R,3R)-1-acetoxy-3-[(2S,3R)-N-benzyl-3-methyl-2-(1-methylpiperidine-2-carboxamido)pentanamido]-4-methylpentyl]thiazole-4-carboxamido]-2-methyl-5-phenylpentanoic acids was prepared and formulated into nanoparticles of polylactate-polyglycolate copolymer. The high cytotoxicity of the compound against 3 tumor cell lines (HL60, HT29 and A2780) was demonstrated. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Recommanded Product: Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

The Article related to tubulysin compound preparation antitumor antimitotic angiogenesis inhibitor pharmaceutical, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 3, 2021, Trofymchuk, Serhii; Bugera, Maksym; Klipkov, Anton A.; Ahunovych, Volodymyr; Razhyk, Bohdan; Semenov, Sergey; Boretskyi, Andrii; Tarasenko, Karen; Mykhailiuk, Pavel K. published an article.HPLC of Formula: 24295-03-2 The title of the article was Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4). And the article contained the following:

A general approach to fluorinated (hetero)aromatic derivatives was elaborated. The key reaction was a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation was fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chem. and agrochem., were synthesized. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).HPLC of Formula: 24295-03-2

The Article related to fluorinated aromatic compound preparation, aryl ketone deoxofluorination sulfur tetrafluoride, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

White, Lisa J.; Boles, Jessica E.; Hilton, Kira L. F.; Ellaby, Rebecca J.; Hiscock, Jennifer R. published an article in 2020, the title of the article was Towards the application of supramolecular self-associating amphiphiles as next-generation delivery vehicles.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole And the article contains the following content:

Herein, we present a series of supramol. self-associating amphiphilic (SSA) salts and establish the potential for these mol. constructs to act as next-generation solution-state mol. delivery vehicles. We characterize the self-association of these SSAs, both alone and when co-formulated with a variety of drug(like) competitive guest species. Single crystal X-ray diffraction studies enable the observation of hydrogen-bonded self-association events in the solid state, while high resolution mass spectrometry confirms the presence of anionic SSA dimers in the gas-phase. These same anionic SSA dimeric species are also identified within a competitive organic solvent environment (DMSO-d6/0.5% H2O). However, extended self-associated aggregates are observed to form under aqueous conditions (H2O/5.0% EtOH) in both the absence and presence of these competitive guest species. Finally, through the completion of these studies, we present a framework to support others in the characterization of such systems. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to drug delivery self associating amphiphile, amphiphile, drug delivery, hydrogen bond, supramolecular chemistry, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica