Day: November 7, 2022

On August 31, 2022, Verma, Diksha; Sharma, Sunita; Sahni, Tanvi; Kaur, Harleen; Kaur, Sukhmanpreet published an article.Synthetic Route of 2010-06-2 The title of the article was Designing, antifungal and structure activity relationship studies of Azomethines and β-lactam derivatives of aza heterocyclic amines. And the article contained the following:

The present investigation deals with the synthesis of seven azomethine derivatives I [R1 = 1,2,4-triazol-4-yl, 2-pyridinyl, 4-phenyl-2-thiazolyl,etc.] of aza heterocyclic amines by carrying out condensation reaction of them with veratraldehyde followed by cyclizing the CH=N moiety in synthesized azomethines of 4-amino-1,2,4-triazole and 4-amino antipyrine to yield β lactam derivatives II [R2 = 1,2,4-triazol-4-yl, 1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl]. The chem. constituents in the synthesized compounds were confirmed by UV, IR, 1H NMR, 13C NMR, and elemental anal. In vitro antifungal activity of all the synthesized products was done against four pathogenic maize fungal strains i.e.Fusarium verticillioides, Macrophomina phaseolina, Rhizoctonia solani, and Dreschlera maydis. It was found that azomethine derivative having 4-amino-1,2,4-triazole ring was as effective as standard carbendazim 50 WP against R. solani and may be considered as promising antifungal agent; therefore further modifications may be done in its structure to get better drug candidate in future. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to dimethoxyphenyl methanimine preparation agrochem antifungal sar, dimethoxyphenylazetidinone preparation agrochem antifungal sar, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 28, 2021, Tu, Dewei; Luo, Juan; Jiang, Wengao; Tang, Qiang published an article.Electric Literature of 24295-03-2 The title of the article was Solvent-free preparation of α,α-dichloroketones with sulfuryl chloride. And the article contained the following:

An efficient and facile method is reported for the synthesis of a series of α,α-dichloroketones. The direct dichlorination of Me ketones and 1,3-dicarbonyls using an excess amount of sulfuryl chloride affords the corresponding gem-dichloro compounds in moderate to excellent yields. Moreover, the protocol features high yields, broad substrate scope and simple reaction conditions without using any catalysts and solvents. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to chlorination methyl ketone sulfuryl chloride, carbonyl compound sulfuryl chloride solvent free chlorination, dichloroketone preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Thomson, Connor J.; Barber, David M.; Dixon, Darren J. published an article in 2020, the title of the article was Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to α-Fluorinated Ketones.Electric Literature of 24295-03-2 And the article contains the following content:

The catalytic enantioselective synthesis of α-fluorinated chiral tertiary alcs. from (hetero)aryl Me ketones is described. The use of a bifunctional iminophosphorane (BIMP) superbase was found to facilitate direct aldol addition by providing the strong Bronsted basicity required for rapid aryl enolate formation. The new synthetic protocol is easy to perform and tolerates a broad range of functionalities and heterocycles with high enantioselectivity (up to >99:1 e.r.). Multi-gram scalability was demonstrated along with catalyst recovery and recycling. 1H NMR studies identified a 1400-fold rate enhancement under BIMP catalysis, compared to the prior state-of-the-art catalytic system. The utility of the aldol products was highlighted with the synthesis of various enantioenriched building blocks and heterocycles, including 1,3-aminoalc., 1,3-diol, oxetane, and isoxazoline derivatives The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to enantioselective catalyst aldol aryl ketone alpha fluorinated, aldol, aryl enolates, enantioselective catalysis, organocatalysis, superbase, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 4, 2021, Polishchuk, Iuliia; Sklyaruk, Jan; Lebedev, Yury; Rueping, Magnus published an article.Application In Synthesis of 2-Acetylthiazole The title of the article was Air Stable Iridium Catalysts for Direct Reductive Amination of Ketones. And the article contained the following:

Half-sandwich iridium complexes bearing bidentate urea-phosphorus ligands I and II were found to catalyze the direct reductive amination of aromatic and aliphatic ketones e.g.,2-Naphthyl Me ketone under mild conditions at 0.5 mol% loading with high selectivity towards primary amines e.g.,1-(naphthalen-2-yl)ethan-1-amine. One of the complexes I was found to be active in both the Leuckart-Wallach (H4CO2H) type reaction as well as in the hydrogenative (H2/NH4AcO) reductive amination. The protocol with ammonium formate does not require an inert atm., dry solvents, as well as additives and in contrast to previous reports takes place in hexafluoroisopropanol (HFIP) instead of methanol. NH4CO2D or D2 is resulted in a high degree of deuterium incorporation into the primary amine α-position. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to primary amine preparation, ketone reductive amination iridium catalyst, deuteration, iridium catalysis, primary amines, reductive amination, General Organic Chemistry: Synthetic Methods and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 6, 2022, Dong, Yuyang; Schuppe, Alexander W.; Mai, Binh Khanh; Liu, Peng; Buchwald, Stephen L. published an article.Related Products of 24295-03-2 The title of the article was Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl-Cu Species. And the article contained the following:

A CuH-catalyzed regiodivergent coupling of vinyl heteroarenes with carbonyl-containing electrophiles, in which the selectivity was controlled by the ancillary ligand. This approach leverages an in situ generated benzyl- or dearomatized allyl-Cu intermediate, yielding either the dearomatized or exocyclic addition products, resp. The method exhibited excellent regio-, diastereo-, and enantioselectivity and tolerated a range of common functional groups and heterocycles. The dearomative pathway allowed direct access to a variety of functionalized saturated heterocyclic structures. The reaction mechanism was probed using a combination of exptl. and computational approach. D. functional theory studies suggested that the ligand-controlled regioselectivity results from the C-H/π interaction and steric repulsion in transition states leading to the major and minor regioisomers, resp. Hydrocupration of vinyl heteroarene pronucleophile was the enantiodetermining step, whereas the diastereoselectivity was enforced by steric interactions between the benzylic or allyl-Cu intermediate and carbonyl-containing substrates in a six-membered cyclic transition state. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Related Products of 24295-03-2

The Article related to vinyl hetero arene aldehyde ketone copper catalyst reductive coupling, hydroxy vinyl heteroarene regio diastereo enantioselective preparation, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2020, Mariammal, Balasubramanian; Shylaja, Adaikalam; Kumar, Sundaravel Vivek; Rubina, Stephen Raja; Kumar, Raju Ranjith published an article.Electric Literature of 24295-03-2 The title of the article was Thiazole-tethered biaryls as fluorescent chemosensors for the selective detection of Fe3+ ions. And the article contained the following:

3-Amino-5-(thiazol-2-yl)-[1,1′-biaryl]-2,4-dicarbonitriles have been synthesized employing a facile one-pot pseudo four-component domino strategy. All these thiazole-tethered biaryls exhibited blue fluorescence under UV lamp. Based on the high relative quantum yield, three compounds namely, 4a, 4d, and 4i, were chosen to explore the metal interference studies. Against several metal ions, these three thiazole-tethered biphenyl probes were found to be effective fluorescent chemosensors for the selective and sensitive detection of Fe3+ ions with a lower detection limit of 0.18, 0.12, and 0.16μM, resp. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to thiazole tethered biaryls fluorescent chemosensor iron, Inorganic Analytical Chemistry: Determinations and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2020, Ruiz-Moyano, Santiago; Hernandez, Alejandro; Galvan, Ana I.; Cordoba, Maria G.; Casquete, Rocio; Serradilla, Manuel J.; Martin, Alberto published an article.COA of Formula: C5H5NOS The title of the article was Selection and application of antifungal VOCs-producing yeasts as biocontrol agents of grey mould in fruits. And the article contained the following:

Rotting caused by gray mold (Botrytis cinerea) is a concerning disease for numerous crops both pre- and postharvest stages. Application of antagonistic yeasts is a promising strategy for controlling gray mold incidence which could mitigate undesirable consequences of using synthetic fungicides. In this work, a screening for detection of yeasts isolated from figs producers of antifungal volatile organic compounds (VOCs) were performed by confrontation in double dishes systems. Eleven out of 34 yeasts confronted reduced B. cinerea growth parameter in vitro. This reduction was correlated (p ≤ 0.050) with the production of 10 volatile compounds: two acids (acetic acid and octanoic acid), 7 esters (Et propionate, n-Pr acetate, Iso-Bu acetate, 2-methylbutyl acetate, furfuryl acetate, phenylmethyl acetate, 2-phenylethyl acetate) and one ketone (Heptan-2-one). In bases on in vitro assay, Hanseniaspora uvarum 793 was applied to in vivo assays with strawberries and cherries. The reduction of incidence of B. cinerea in strawberries at 7°C and 25°C was 54.9 and 72.1% after 6 and 3 days, resp. The reduction of incidence of B. cinerea in cherries at 7°C and 25°C was 48.9 and 45.6% after 5 and 4 days, resp. These results showed that VOCs produced by Hanseniaspora uvarum 793 are effective in the control of incidence of Botrytis cinerea in fruits, being a potential alternative to chem. fungicide. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).COA of Formula: C5H5NOS

The Article related to antifungal volatile compound yeast gray mold fruit, antifungal volatile compounds, botrytis cinerea, cherry, postharvest, strawberry, Food and Feed Chemistry: Feeds and Animal Foods and other aspects.COA of Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 24, 2017, Liu, Denggui; Yang, Kunyu; Zhou, Wei; Chen, Hao; Zeng, Qingdong published a patent.Quality Control of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate The title of the patent was Preparation of 2-(4-methyl-1-oxo-2-penten-1-yl)-4-thiazolecarboxylic acid ethyl ester. And the patent contained the following:

The invention discloses a preparation method of anti-cancer medicament intermediate, using glyceraldehyde acetonide and L-cysteine hydrochloride as raw materials, through steps such as cyclization, oxidation, de-propylidene, reoxidizing, and halohydrin to obtain an intermediate compound, which was further reacted with isobutyric aldehyde through Wittig, and compound 2-(4-methyl-1-oxo-2-penten-1-yl)-4-thiazolecarboxylic acid Et ester is obtained. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Quality Control of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

The Article related to thiazolecarboxylic acid ethyl ester preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Quality Control of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2021, Berenguer, Cristina; Pereira, Jorge A. M.; Camara, Jose S. published an article.SDS of cas: 24295-03-2 The title of the article was Fingerprinting the volatile profile of traditional tobacco and e-cigarettes: A comparative study. And the article contained the following:

Electronic cigarettes (e-cigarettes) have become popular alternatives to traditional tobacco. Despite this, a comprehensive evaluation of their long-term effects and safety for the consumers and the environment is missing. To contribute to filling this gap, headspace solid-phase microextraction combined with gas chromatog.-mass spectrometry (HS-SPME/GC-MS) was employed to establish and compare the volatile fingerprints of traditional tobacco and e-cigarettes. The anal. of traditional tobacco included two popular brands and different parts of the cigarette (solid tobacco, cigarette smoke, cigarette paper and filter). Regarding the e-cigarettes, two e-liquids, with and without nicotine, their main constituents (e-bases) and corresponding vapors, obtained under default vaping (power) conditions, were analyzed. A total of 80 volatile organic compounds (VOCs) were identified in traditional tobacco, of which 14 carbonyl compounds, 9 benzene derivatives, 9 Et esters and 9 hydrocarbons. Slight differences in the volatile profile of cigarette paper and filter between the two brands were also detected, showing that exogenous components of tobacco influence the flavor and harmfulness perceived by the smokers. In turn, 92 VOCs were identified in e-cigarettes, including 31 Et esters, 18 alcs. and 10 hydrocarbons. No VOCs with potentially toxic or harmful effects were identified in the vapor of Do It Yourself (DIY) liquids and Premium samples. Therefore, taking into consideration the volatile compositions obtained for smoking and vaping procedures under normal conditions of operation and using certified e-liquid mixtures, the e-cigarettes analyzed seemed to constitute a valid and less harmful alternative to traditional tobacco for smokers, second-hand smokers and the environment. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).SDS of cas: 24295-03-2

The Article related to traditional tobacco cigarette volatile profile fingerprinting, Plant Biochemistry: Tobacco and Tobacco Products and other aspects.SDS of cas: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2021, Hu, Yuanyuan; Hu, Chunfang; Pan, Guangxing; Yu, Congwei; Ansari, Mohammad Fawad; Yadav Bheemanaboina, Rammohan R.; Cheng, Yu; Zhou, Chenghe; Zhang, Jiaheng published an article.Formula: C5H5NOS The title of the article was Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. And the article contained the following:

The increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics has led to a growing effort to design and synthesize novel structural candidates of chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids with outstanding bacteriostatic potential. Bioactivity screening showed that hybrid 5i, which was modified with methoxybenzene, exerted a significant inhibitory activity against MRSA (MIC = 0.004 mM), which was 6 times better than the anti-MRSA activity of the reference drug norfloxacin (MIC = 0.025 mM). Compound 5i neither conferred apparent resistance onto MRSA strains even after multiple passages nor triggered evident toxicity to human hepatocyte LO2 cells and normal mammalian cells (RAW 264.7). Mol. docking showed that highly active mol. 5i might bind to DNA gyrase by forming stable hydrogen bonds. In addition, mol. electrostatic potential surfaces were developed to explain the high antibacterial activity of the target compounds Furthermore, preliminary mechanism studies suggested that hybrid 5i could disrupt the bacterial membrane of MRSA and insert itself into MRSA DNA to impede its replication, thus possibly becoming a potential antibacterial repressor against MRSA. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to staphylococcus methicillin resistance antibacterial chalcone macrophage hepatocyte, antibacterial, chalcone, coumarin, dna, mrsa, thiazole, Microbial, Algal, and Fungal Biochemistry: Other and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica