Boles, Jessica E.; Bennett, Charlotte; Baker, Jennifer; Hilton, Kira L. F.; Kotak, Hiral A.; Clark, Ewan R.; Long, Yifan; White, Lisa J.; Lai, Hin Yuk; Hind, Charlotte K.; Sutton, J. Mark; Garrett, Michelle D.; Cheasty, Anne; Ortega-Roldan, Jose L.; Charles, Mark; Haynes, Cally J. E.; Hiscock, Jennifer R. published an article in 2022, the title of the article was Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of ′druggable′ supramolecular self-associating antimicrobial amphiphiles.Synthetic Route of 92-36-4 And the article contains the following content:
The rise of antimicrobial resistance remains one of the greatest global health threats facing humanity. Furthermore, the development of novel antibiotics has all but ground to a halt due to a collision of intersectional pressures. Herein we determine the antimicrobial efficacy for 14 structurally related supramol. self-associating amphiphiles against clin. relevant Gram-pos. methicillin resistant Staphylococcus aureus and Gram-neg. Escherichia coli. We establish the ability of these agents to selectively target phospholipid membranes of differing compositions, through a combination of computational host:guest complex formation simulations, synthetic vesicle lysis, adhesion and membrane fluidity experiments, alongside our novel 1H NMR CPMG nanodisc coordination assays, to verify a potential mode of action for this class of compounds and enable the production of evermore effective next-generation antimicrobial agents. Finally, we select a 7-compound subset, showing two lead compounds to exhibit ′druggable′ profiles through completion of a variety of in vivo and in vitro DMPK studies. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Synthetic Route of 92-36-4
The Article related to phospholipid druggable supramol self associating amphiphile antimicrobial, Placeholder for records without volume info and other aspects.Synthetic Route of 92-36-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica