On March 20, 2003, Deghati, Paymaneh Y. F.; Borghini, Alice; Van Den Nieuwendijk, Adrianus M. C. H.; Dissen-de Groote, Miriam; IJzerman, Adriaan P. published an article.Recommanded Product: 19989-66-3 The title of the article was Inhibition of nucleoside transport By new analogues of nitrobenzylthioinosine. And the article contained the following:
Nitrobenzylthioinosine (NBTI, 1) was systematically modified by attachment of substituents at positions C6 and N9, and also by substitution of N1 with C. These modifications were chosen to reduce the polarity of the new compounds Incorporation of the nitro functionality into a benzoxadiazole ring system was considered first. These new nucleosides showed high affinity (1.5-10 nM) towards the nucleoside transport protein as present on human erythrocyte ghosts. Next, modification of this benzoxadiazole ring system with C, S and O in different positions produced a number of less polar nucleosides with affinity in the higher nanomolar range. Modification of N9 was achieved with different alkyl and alc. substituents. An Bu substituent proved best, although all variations yielded substantial decreases in affinity. Replacement of N1 by a carbon atom in combination with a 2-Cl substituent also resulted in a relatively potent NBTI derivative (47 nM). The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Recommanded Product: 19989-66-3
The Article related to nitrobenzylthioinosine analog preparation structure activity nucleoside transport protein, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 19989-66-3
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica