On June 30, 2022, Rajeswari, Kannuri; Manturthi, Shireesha; Sirisha, Kalam; Velidandi, Amar nath published an article.Safety of 2-Acetylthiazole The title of the article was Anchoring and Hydrophobic Nature of Coumarin in Newer Coumarin Based Chalcones: Synthesis, In Silico, and In Vitro Cell Viability Studies. And the article contained the following:
Coumarin is active pharmacophore; to enhance the activity of chalcone we inserted coumarin along with other cyclic groups. Fewer pyrazolone aldehydes produced using Wills Maeyer Haack reaction by grinding method. In alc. sodium hydroxide, cyclic ketones react with aldehydes to produce title compounds To treat the ill cell a drug must be with a linker, anchoring group, and hydrophobic group. Herein, the enone group acts as a linker, the rings on both sides are connected, one side ring acts as the anchoring group, and the other side ring acts as the hydrophobic group; anchoring, hydrophobic dual roles played by coumarin ring. In this series, In silico studies results have shown that many compounds of this series potent for anti-cancer activity along with other biol. activities, the In vitro cell viability studies of the series shows that, chalcone (I), (VIII), and (IV) are having IC50 values 2.96, 2.97, and 2.82 μM against call 27 (or) oral cancer cell line. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Safety of 2-Acetylthiazole
The Article related to oral cancer coumarin chalcone cell viability hydrophobic, Placeholder for records without volume info and other aspects.Safety of 2-Acetylthiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica