On February 23, 2005, Solbach, C.; Uebele, M.; Reischl, G.; Machulla, H.-J. published an article.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for β-amyloid imaging in Alzheimer’s Disease with PET. And the article contained the following:
The synthesis of carbon-11 amino function labeled uncharged Thioflavin T derivatives is known to be performed by reaction of the demethyl-precursors with [11C]methyl iodide but the labeling yields are only mediocre. The use of [11C]methyl triflate improved the radiochem. yield of three potential β-amyloid imaging PET-radiotracers significantly. Performance of the labeling reaction by reacting the corresponding precursor mols. with [11C]methyl triflate for 1 min at 80° led to radiochem. yields of 44±10% (n = 5) for [11C]6-Me-BTA-1, 68±4% (n = 10) for [11C]BTA-1 and 58±2% (n = 5) for [11C]6-OH-BTA-1 with respect to [11C]methyl triflate. In production runs (60 min, 50 μA) up to 6500 MBq (mean: 4000±1900 MBq) of [11C]6-Me-BTA-1, 7900 MBq (mean: 6000±1000 MBq) of [11C]BTA-1 and 7100 MBq (mean: 6300±600 MBq) of [11C]6-OH-BTA-1 could be obtained ready for i.v. injection. The radiochem. purity was >95% with specific activities in the range of 80-120 GBq/μmol (EOS) within a total synthesis time of less than 40 min after EOB. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole
The Article related to radiosynthesis carbon 11 methyl triflate thioflavin t derivative, beta amyloid alzheimer disease pet imaging agent, Pharmaceuticals: Pharmaceutics and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica