Aursnes, M. published the artcileStereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator, Safety of (S)-4-Benzylthiazolidine-2-thione, the main research area is protectin D1 stereoselective synthesis antiinflammatory proresolving lipid mediator; Wittig reaction Evans Aldol hydrogenation Lindlar catalyst chiral auxiliary.
A convergent stereoselective synthesis of the potent anti-inflammatory, proresolving and neuroprotective lipid mediator protectin D1 has been achieved in 15% yield over eight steps. The key features were a stereocontrolled Evans-aldol reaction with Nagao’s chiral auxiliary and a highly selective Lindlar reduction of internal alkyne (I) , allowing the sensitive conjugated E,E,Z-triene to be introduced late in the preparation of protectin D1. The UV and LC/MS-MS data of synthetic protectin D1 matched those obtained from endogenously produced material.
Organic & Biomolecular Chemistry published new progress about Aldol addition, stereoselective. 171877-39-7 belongs to class thiazole, name is (S)-4-Benzylthiazolidine-2-thione, and the molecular formula is C10H11NS2, Safety of (S)-4-Benzylthiazolidine-2-thione.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica