Button, Richard G.’s team published research in Journal of the Chemical Society, Perkin Transactions 11: Physical Organic Chemistry in 1973 | CAS: 16441-28-4

Journal of the Chemical Society, Perkin Transactions 11: Physical Organic Chemistry published new progress about Decarboxylation. 16441-28-4 belongs to class thiazole, name is 2-(2-Phenylthiazol-4-yl)acetic acid, and the molecular formula is C11H9NO2S, Product Details of C11H9NO2S.

Button, Richard G. published the artcileDecarboxylation of heterocyclic acetic acids. II. Direct and indirect evidence for the zwitterionic mechanism, Product Details of C11H9NO2S, the main research area is pyridylacetate decarboxylation; heterocyclic acetate decarboxylation; tautomerism decarboxylation heterocycle; zwitterion decarboxylation heterocycle.

Microscopic and model pKa values were determined for 2- and 4-pyridylacetic acids in aqueous 2-propanol, and used to determine microscopic pKa values as a function of solvent composition Calculation of the mode fractions of zwitterionic and neutral forms allowed the decarboxylation rates to be reexpressed in terms of these species as kZ, and kN, resp. Correlation of kZ, but not kN, with solvent composition showed that decarboxylation is via the zwitterion. Similar calculations, with allowance for tautomerism, showed that 8 other heterocyclic acetic acids decarboxylate by the same mechanism. β-Keto acids may also decarboxylate via a zwitterion.

Journal of the Chemical Society, Perkin Transactions 11: Physical Organic Chemistry published new progress about Decarboxylation. 16441-28-4 belongs to class thiazole, name is 2-(2-Phenylthiazol-4-yl)acetic acid, and the molecular formula is C11H9NO2S, Product Details of C11H9NO2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica