Nagashima, Shinya’s team published research in Bioorganic & Medicinal Chemistry in 2014-07-01 | CAS: 99822-80-7

Bioorganic & Medicinal Chemistry published new progress about Bronchodilators. 99822-80-7 belongs to class thiazole, name is Ethyl 4-phenylthiazole-5-carboxylate, and the molecular formula is C12H11NO2S, Safety of Ethyl 4-phenylthiazole-5-carboxylate.

Nagashima, Shinya published the artcileNovel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists, Safety of Ethyl 4-phenylthiazole-5-carboxylate, the main research area is quinuclidinyl heteroarylcarbamate derivative preparation muscarinic receptor antagonist; ASP9133; COPD; In vivo selectivity; Long acting muscarinic receptor antagonist.

Herein, we describe the synthesis and pharmacol. profiles of novel quinuclidinyl heteroarylcarbamate derivatives Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.

Bioorganic & Medicinal Chemistry published new progress about Bronchodilators. 99822-80-7 belongs to class thiazole, name is Ethyl 4-phenylthiazole-5-carboxylate, and the molecular formula is C12H11NO2S, Safety of Ethyl 4-phenylthiazole-5-carboxylate.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica