Nomura, Masahiro published the artcileDiscovery of cyclic amine-substituted benzoic acids as PPARα agonists, Product Details of C11H8FNO2S, the main research area is benzoic acid cyclic amine substituted preparation SAR PPAR agonist.
A series of novel cyclic amine-substituted benzoic acid derivatives was synthesized and evaluated for PPARα agonist activity. Structure-activity relationship studies led to the identification of (S)-3-[3-[2-(4-chlorophenyl)-4-methylthiazole-5-carboxamido]piperidin-1-yl]benzoic acid (I) (KRP-105) as a potent and high subtype-selective human PPARα agonist. I showed excellent PK profile, and oral administration of I to high-fat diet dogs effectively lowered triglycerides.
Bioorganic & Medicinal Chemistry Letters published new progress about Cyclic amines Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 144060-99-1 belongs to class thiazole, name is 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid, and the molecular formula is C11H8FNO2S, Product Details of C11H8FNO2S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica