Yamaguchi, Kohji published the artcile4-phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice, SDS of cas: 99822-80-7, the main research area is phenylthiazole derivative osteoblast interleukin6 secretion; osteoporosis phenylthiazole derivative structure.
A series of 4-phenylthiazole derivatives were synthesized and tested their inhibitory effect on the interleukin-6 secretion stimulated by PTH in osteoblastic cells. SCRC2941-18, 2-amino-4-(4-chlorophenyl)-5-methylthiazole, was found to be the most potent inhibitor in the derivatives Furthermore, SCRC2941-18 significantly suppressed the bone weight loss in the ovariectomized mice, an osteoporosis model.
Bioorganic & Medicinal Chemistry Letters published new progress about Interleukin 6 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 99822-80-7 belongs to class thiazole, name is Ethyl 4-phenylthiazole-5-carboxylate, and the molecular formula is C12H11NO2S, SDS of cas: 99822-80-7.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica