Zhao, Gang published the artcileDesign and development of some thiazole-based flavanoids as novel antibacterial against pathogens causing surgical site infection for possible benefit in bone trauma via inhibition of DNA gyrase, Safety of 4-(2-Nitrophenyl)thiazole-2-amine, the main research area is thiazole flavanoid synthesis antibacterial DNA gyrase bone trauma infection; DNA gyrase; antibacterial activity; docking; flavanoid; thiazole.
In this study, a novel class of hybrid thiazole-based flavanoid derivatives were synthesized and characterized by FT-IR, 1H-NMR, 13C-NMR, mass and elemental anal. These derivatives were evaluated for antibacterial activity for possible benefit in bone trauma via inhibition of DNA gyrase enzyme. Results suggested that compounds I, II, and III showed considerable inhibition of DNA gyrase with considerable activity against tested forty strains of Staphylococcus aureus clin. isolates. Moreover, compound I showed hydrogen bonding with LYS460 along with low binding free energy of -4.36 kcal/mol against DNA gyrase enzyme. The hemolytic activity of the potent compounds showed mild to no activity together with excellent pharmacokinetics, suggesting to have a potential for the development of designed compounds as novel antibacterial agents.
Chemical Biology & Drug Design published new progress about Antibacterial agents. 90323-06-1 belongs to class thiazole, name is 4-(2-Nitrophenyl)thiazole-2-amine, and the molecular formula is C9H7N3O2S, Safety of 4-(2-Nitrophenyl)thiazole-2-amine.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica