Day: November 21, 2022

Zhang, Yifei published the artcileInhibitors in Commercially Available 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonate) Affect Enzymatic Assays, Quality Control of 30931-67-0, the publication is Analytical Chemistry (Washington, DC, United States) (2020), 92(1), 1502-1510, database is CAplus and MEDLINE.

ABTS, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate), is a common chromogenic substrate for peroxidase enzymes, which are widely used in biochem. research and diagnostic tests. We discovered that impurities in the com. available ABTS significantly affect the results of peroxidase activity assays. We show that the impurities inhibit the activity of the peroxidases and the influence varies for different batches of ABTS from the same source. The inhibition of horseradish peroxidase (HRP) is uncompetitive for the substrate H₂O₂ while it is competitive for the substrate ABTS. By using high-resolution mass spectrometry, potential inhibitors were identified to be precursors or analogs of ABTS. The inhibitors are also capable of inhibiting the GOx-catalyzed reduction of the ABTS radical cation by glucose in anaerobic conditions. As the inhibition is found to be pH-dependent, diagnostic applications, such as ELISA tests based on the peroxidase-H₂O₂-ABTS system, should be carried out at pH 4.4 to minimize the inhibitory effect of potentially present impurities.

Analytical Chemistry (Washington, DC, United States) published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C9H10O3S, Quality Control of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ward, E. R. published the artcile1,2,3-Benzothiadiazole. III. Electrophilic substitution in 5- and 7-amino-1,2,3-benzothiadiazoles and the preparation of some substituted 1,2,3-benzothiadiazoles, Application of Benzo[d][1,2,3]thiadiazol-5-amine, the publication is Journal of the Chemical Society (1965), 1023-8, database is CAplus.

cf. CA 59:12787f. Bromination, iodination, nitration, and diazo-coupling of 5- and 7-amino-1,2,3-benzothiadiazoles, and some N-acyl derivatives, have been studied. The results largely confirm the interpretation of electrophilic substitution in the 1,2,3-benzothiadiazole system previously advanced. Some bromination reactions probably proceed by mechanisms other than simple electrophilic substitution. Spectroscopic anal. of the mixture of 5- and 7-nitro-1,2,3-benzothiadiazoles, obtained by nitration of the parent compound, shows that the 7-nitro isomer predominates. Preparation of nitro-, amino-, and hydroxy-1,2,3-benzothiadiazoles has been further investigated, particular attention being given to methods involving ring opening of appropriate benzothiazoles. The synthesis of 4-hydroxy-1,2,3-benzothiadiazole, an analog of 8-hydroxyquinoline, is described.

Journal of the Chemical Society published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C11H14O4, Application of Benzo[d][1,2,3]thiadiazol-5-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Dou, Henri J. M. published the artcileS-alkylation in the heterocyclic series by phase transfer catalysis: 2-alkylthiothiazoles, 2-alkylthio-Δ⁴-thiazolines and 2-alkylthiobenzothiazoles, HPLC of Formula: 5053-24-7, the publication is Helvetica Chimica Acta (1978), 61(8), 3143-8, database is CAplus.

4-Thiazoline-2-thiones, 2-thiazolidinethione, and 2-benzothiazolinethione were S-alkylated with MeI and alkyl bromides under phase transfer catalysis by PhCH₂N⁺Et₃ Cl^– or Bu₄N⁺ Br^– to give 80-90% alkylthio derivatives Similar reaction of 2-bromothiazole with mercaptans gave only low yields of alkylthiothiazoles, accompanied by dequaternization of the catalyst.

Helvetica Chimica Acta published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, HPLC of Formula: 5053-24-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

ElyasiGhahfarokhi, Azam published the artcilePhytocatalytic and cytotoxic activity of the purified laccase from bled resin of Pistacia atlantica Desf., Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is International Journal of Biological Macromolecules (2021), 394-403, database is CAplus and MEDLINE.

This study reports an efficient and fast procedure for the purification of laccase (PaL) obtained from the resin of Pistacia atlantica Desf. It was purified by one-step affinity chromatog. and showed the specific activity of 393 U/mg with 81.9-fold purification The mol. weight of PaL was estimated to be approx. 60 kDa using gel electrophoresis SDS-PAGE. Moreover, it depicted diphenolase activity and high affinity towards 2,6-dimethoxy phenol (Km = 10.01 ± 0.5 mM) and syringaldazine (Km = 6.57 ± 0.2 mM) comparing with plant-origin polyphenol oxidases reported in the literature. It should be noted that PaL possessed optimal activity at pH 7.5 and 45°C. It also remained stable under different conditions of pH (6.5-8.0), temperature (25-45°C), and when it was exposed to several metal ions. The MTT and flow cytometry assays demonstrated that the enzyme treatment significantly affected growth of HeLa, HepG2, and MDA-MB-231 cells with LC50 values of 4.83 ± 0.02, 61 ± 0.31, and 26.83 ± 0.11μM after 72 h, resp. This is the first attempt to isolate and characterize a new oxidoreductase from the resin of Pistacia atlantica Desf., native species of Iran, to recruit it in cytotoxicity researches. In the purification process by an efficient affinity column (SBA-NH2-GA), the enzyme was eluted promptly with a satisfied yield. The purified laccase exerted higher affinity to diphenolic compounds and pH-thermal stability compared to other plant-derived polyphenol oxidases. The purified enzyme was found to show anti-oxidant capacity and significantly inhibited the growth of cancerous cells in vitro. PaL showed more cytotoxic activity towards HeLa and MDA-MB-231 cells by induction of apoptosis. The cytotoxic activity of the laccase was measured by flow cytometry.

International Journal of Biological Macromolecules published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Larsen, Matthew A. published the artcileIridium-Catalyzed C-H Borylation of Heteroarenes: Scope, Regioselectivity, Application to Late-Stage Functionalization, and Mechanism, HPLC of Formula: 791614-90-9, the publication is Journal of the American Chemical Society (2014), 136(11), 4287-4299, database is CAplus and MEDLINE.

A study on the iridium-catalyzed C-H borylation of heteroarenes is reported. Several heteroarenes containing multiple heteroatoms were amenable to C-H borylation catalyzed by the combination of an iridium(I) precursor and tetramethylphenanthroline. The investigations of the scope of the reaction led to the development of powerful rules for predicting the regioselectivity of borylation, foremost of which is that borylation occurs distal to nitrogen atoms. One-pot functionalizations are reported of the heteroaryl boronate esters formed in situ, demonstrating the usefulness of the reported methodol. for the synthesis of complex heteroaryl structures. Application of this methodol. to the synthesis and late-stage functionalization of biol. active compounds is also demonstrated. Mechanistic studies show that basic heteroarenes can bind to the catalyst and alter the resting state from the olefin-bound complex observed during arene borylation to a species containing a bound heteroarene, leading to catalyst deactivation. Studies on the origins of the observed regioselectivity show that borylation occurs distal to N-H bonds due to rapid N-H borylation, creating an unfavorable steric environment for borylation adjacent to these bonds. Computational studies and mechanistic studies show that the lack of observable borylation of C-H bonds adjacent to basic nitrogen is not the result of coordination to a bulky Lewis acid prior to C-H activation, but the combination of a higher-energy pathway for the borylation of these bonds relative to other C-H bonds and the instability of the products formed from borylation adjacent to basic nitrogen.

Journal of the American Chemical Society published new progress about 791614-90-9. 791614-90-9 belongs to thiazole, auxiliary class Boronate Esters,Boronic acid and ester,Boronic acid and ester, name is 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole, and the molecular formula is C14H18BNO2S, HPLC of Formula: 791614-90-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kamel, M. published the artcileHeterocyclic azo dyes. V. Further studies on azo dyes containing a benzothiadiazole ring, HPLC of Formula: 1753-29-3, the publication is Kolorisztikai Ertesito (1976), 18(5-6), 155-61, database is CAplus.

Disperse and acid dyes were prepared by coupling 5-hydroxy-1,2,3-benzothiadiazole (I) [7686-40-0] with various aromatic amines, and their dyeing and fastness properties on nylon 66 or wool were determined The disperse dyes showed poor affinity for nylon (except at high temperature) in contrast to corresponding dyes from 5-amino-1,2,3-benzothiadiazole which have good affinity; the latter dyes also show better light- and washfastness. All the acid dyes, prepared by coupling I with diazotized naphthylamine sulfonic acids, showed good affinity for wool and good leveling properties; light- and washfastness were 2-3 and 3-4, resp.

Kolorisztikai Ertesito published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C6H5N3S, HPLC of Formula: 1753-29-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kmari, Sangeeta published the artcileSynthesis, characterization & pharmacological activity of 1,2,4-triazole derivatives (Z)-1(benzo[d]thiazole-2-yl)(1-subsituted phenylidene) hydrazine containing benzothiazole, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2021), 10(11), 1204-1214, database is CAplus.

The present study shows effort to synthesize new triazole products I (R = 3-nitrol, 2,5-dihydroxy, 2-bromo-4-chloro, etc.) and measure them for anti-convulsion action through Maximal electrode shock attack method. First step, aniline and potassium thiocynate were synthesized and reacted through using bromine solution and glacial acetic acid formaylation and gave complex 6-chlorobenzo[d] thiazole-2-amine. The above compound 6-chlorobenzo[d] thiazole-2-amine was once responded by way of 6-chlorobenzo[d] thiazole-2-amine in the occurrence of ethylene glycol, and hydrazine hydrate to present 1-(6-chlorobenzo[d] thiazole-2yl) hydrazine (II). Complex II used to be allowable to reply with numerous substituted potassium thiocynate offers conforming triazole products. Triazole products II had been replied through acetophenone and giacial acetic acid and ethanol at reflux for 5h to afford complexes I. Last triazole (Z)-1-(benzo[d] thiazole-2-yl)-2-(1-subsituted phenylthylidene) hydrazine I, was synthesized from substituted acetophenone through the response with ethanol. Pharmacol. screening through an ear electrode prompted cutting-edge 51mA for 0.3 2d in electro-convulsiometer for anti-conversant activity. The synthesized compound Is used to be I. The complicated I (R = 4-methoxy, 4-hydroxy) was once set up to be maximum powerful complicated with associate to general medications phenytoin sodium.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ji, Feixiang published the artcileExcited state electronic structures and photochemistry of different oxidation states of 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), Computed Properties of 30931-67-0, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2021), 119503, database is CAplus and MEDLINE.

The mol. structures of 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), were calculated by using time-dependent d. functional theory (TDDFT) model with M062X method with 6-311G (d, p) basis set. In this work, the ABTS were theor. investigated from the geometric structure, the energy levels of the LUMO (LUMO) and the HOMO (HOMO), the energy level gap ΔEHOMO-LUMO of the mol. ground state, excited stated properties and the electronic absorption spectra of different oxidation states. We studied the energy levels of LUMO and HOMO of ABTS in different oxidation states. Frontier MO anal. can provide insight into the nature of excited states. ABTS was synthesized from N-ethylaniline by total synthesis. Then, we measured the UV-Vis spectra of ABTS before and after being oxidized by K₂S₂O₈. The calculated electronic structures and photochem. properties of different oxidation state of ABTS were in accordance with the exptl. result. This work demonstrates the relationship between the electronic structures and photochem. of different oxidation states ABTS hence paves the way for the rationally synthesis and deepen understanding of the photophys. properties of ABTS materials.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Computed Properties of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chen, Binhui published the artcileSelective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts, Related Products of thiazole, the publication is Organic Letters (2015), 17(19), 4698-4701, database is CAplus and MEDLINE.

A highly selective construction of 4-substituted 2-aminothiazoles and 4-substituted 5-thiocyano-2-aminothiazoles, resp., catalyzed by palladium(II) acetate and promoted by iron(III) bromide from vinyl azides and potassium thiocyanate has been developed. E.g., reaction of PhC(:CH₂)N₃ with potassium thiocyanate, catalyzed by palladium(II) acetate gave 90% 2-aminothiazole derivative (I). Use of readily available starting materials, high selectivity, as well as mild reaction conditions make this practical method particularly attractive.

Organic Letters published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wu, Yue published the artcileIron-catalyzed tandem oxidative coupling and acetal hydrolysis reaction to prepare formylated benzothiazoles and isoquinolines, Computed Properties of 95-24-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(26), 3271-3274, database is CAplus and MEDLINE.

The direct formylation of benzothiazoles and isoquinolines was reported. The reaction features a novel iron-catalyzed Minisci-type oxidative coupling process using com. available 1,3-dioxolane as a formylated reagent followed by acetal hydrolysis without a separation process. The reaction was performed under exceedingly mild reaction conditions and exhibited broad functional group tolerance.

Chemical Communications (Cambridge, United Kingdom) published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C10H10O2, Computed Properties of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica