Chalopin, T. published the artcileSecond generation of thiazolylmannosides, FimH antagonists for E. coli-induced Crohn’s disease, Computed Properties of 885229-41-4, the publication is Organic & Biomolecular Chemistry (2016), 14(16), 3913-3925, database is CAplus and MEDLINE.
The anti-adhesive strategy, consisting of disrupting bacterial attachment to the host cells, is widely explored as an alternative to antibiotic therapies. Recently, thiazolylmannosides (TazMans) have been identified as strong anti-adhesives of E. coli strains implied in the gut inflammation of patients with Crohn’s disease. In this work, we developed a second generation of TazMans with improved chem. stability. The anomeric nitrogen was substituted by short linkers and the compounds were assessed against the bacterial adhesion FimH and the clin. isolated LF82 E. coli strain in four in vitro assays. The results obtained on the FimH adhesion alone and the whole bacteria enabled the identification of a candidate for further in vivo evaluations.
Organic & Biomolecular Chemistry published new progress about 885229-41-4. 885229-41-4 belongs to thiazole, auxiliary class Thiazole,Chloride,Ketone, name is 1-(2-Chlorothiazol-5-yl)ethanone, and the molecular formula is C5H4ClNOS, Computed Properties of 885229-41-4.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica