Chanon, Michel published the artcileAlkylation reactions of thiazoles. II. Comparative study of the pK(sub a) values of various 2-(methylthio)thiazoles and of their kinetic constants in the reaction with methyl iodide, Product Details of C4H5NS2, the publication is Bulletin de la Societe Chimique de France (1968), 2885-9, database is CAplus.
The 4- (I) and 5-di-Me derivatives (II) of 2-(methylthio)thiazole were treated with MeI in Me2CO at 20, 25, and 30° and the reaction site, order of reaction, and the magnitude of activation determined The pKa values of the bases were measured. The pKa values were lowered by the influence of the methylthio group; the protonation reaction on N was less sensitive to steric effects than acylation; the methylthio group withdrew the electrons in the thiazole ring and sterically hindered the reaction site; and the Me substituent increased the rate constants
Bulletin de la Societe Chimique de France published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Product Details of C4H5NS2.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica