Hoveyda, Hamid R.’s team published research in ACS Medicinal Chemistry Letters in 6 | CAS: 1375066-73-1

ACS Medicinal Chemistry Letters published new progress about 1375066-73-1. 1375066-73-1 belongs to thiazole, auxiliary class Thiadiazole,Hydrazine,Amine,Hydrazide,Amide, name is 3-Methyl-1,2,4-thiadiazole-5-carbohydrazide, and the molecular formula is C4H6N4OS, Name: 3-Methyl-1,2,4-thiadiazole-5-carbohydrazide.

Hoveyda, Hamid R. published the artcileOptimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II), Name: 3-Methyl-1,2,4-thiadiazole-5-carbohydrazide, the publication is ACS Medicinal Chemistry Letters (2015), 6(7), 736-740, database is CAplus and MEDLINE.

Further lead optimization on N-acyl-triazolopiperazine antagonists to the neurokinin-3 receptor (NK3R) based on the concurrent improvement in bioactivity and ligand lipophilic efficiency (LLE) is reported. Overall, compound I (LLE > 6) emerged as the most efficacious in castrated rat and monkey to lower plasma LH, and it displayed the best off-target safety profile that led to its clin. candidate nomination for the treatment of sex-hormone disorders.

ACS Medicinal Chemistry Letters published new progress about 1375066-73-1. 1375066-73-1 belongs to thiazole, auxiliary class Thiadiazole,Hydrazine,Amine,Hydrazide,Amide, name is 3-Methyl-1,2,4-thiadiazole-5-carbohydrazide, and the molecular formula is C4H6N4OS, Name: 3-Methyl-1,2,4-thiadiazole-5-carbohydrazide.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica