Jiang, Fengchao’s team published research in Yaoxue Xuebao in 41 | CAS: 56503-96-9

Yaoxue Xuebao published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine.

Jiang, Fengchao published the artcileThe design and synthesis of 2-aminothiazole derivatives and their inhibitory activity on apoptosis, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Yaoxue Xuebao (2006), 41(8), 727-734, database is CAplus and MEDLINE.

The objective of this study is to investigate the inhibitory effect of 2-aminothiazole derivatives on Neuro-cell apoptosis and QSAR. The 2-aminothiazole derivatives were designed and synthesized based on the lead compound of PFT-α, the protective action of the compounds against and their inhibitory action on PC12 cell apoptosis induced by H2O2 were determined by MTT method and FCM method. The QSAR equation was obtained from Cerius2-QSAR+ module. Eleven novel 2-aminothiazole Schiff base compounds(II) have been designed and synthesized. The structure of the final compound were characterized by IR, MS, 1HNMR, 13 CNMR. Their protective action against and the inhibitory action on PC12 cell apoptosis induced by H2O2 were found in this experiment The optimal QSAR equation obtained from the Cerius2-QSAR+ module by using log (1 /EC50) with corresponding descriptors is Activity = 6.94768 – 0.08872*”LUMO”- 0.043018*”Alogp98″- 0.128752*”Rad0fGration”+ 0.018246*”Dipole-mag”. The correlation statistics parameters of the above equation are as follows: r2 = 0.970, F-test = 49.149, r = 0.985 and Lse = 0.001. The 2-aminothiazole derivatives exhibited certain activity in inhibiting PC12 cell apoptosis induced by H2O2. Some compounds have the dual activities, the protective action against and inhibitory action on PC12 cell apoptosis induced by H2O2. The QSAR equation indicated that it is favorable for enhance the activity of 2-aminothiazole derivatives by the reduction of “radius of gyration” and the energy of “LUMO”of the compounds

Yaoxue Xuebao published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica