Kennedy, G. L. Jr. published the artcileInhalation toxicity of dehydrothio-p-toluidine, Category: thiazole, the publication is Food and Chemical Toxicology (1984), 22(4), 289-92, database is CAplus and MEDLINE.
The acute inhalation toxicity of dehydrothio-p-toluidine (DHPT)(I) [92-36-4] was determined by exposing groups of young adult rats for single 4-h periods. Death resulted when the DHPT concentration reached 3.00 mg/L. The subchronic effects of DHPT were studied by exposing male rats to 0.6 mg/L for 10 6-h periods (5 exposure days, 2 rest days, 5 exposure days). Body-weight loss during the exposures was followed by normal weight gain during a 14-day recovery period. Salivation, lacrymation, pawing and chewing motions, rapid respiration, and red nasal discharge occurred during exposure and continued into the recovery period, although they generally abated as the recovery period progressed. Clin. laboratory measurements on blood from exposed rats suggested a hemolytic anemia with injury to the liver and kidneys. Liver changes were characterized by hepatocyte hypertrophy and proliferation of bile-duct epithelial cells. A mild degree of renal tubular degeneration was seen and the spleen showed congestion of red pulp with excessive amounts of hemosiderin. These effects persisted throughout the 2-wk recovery period.
Food and Chemical Toxicology published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica