Krintel, Christian published the artcileEnthalpy-entropy compensation in the binding of modulators at ionotropic glutamate receptor GluA2, Category: thiazole, the publication is Biophysical Journal (2016), 110(11), 2397-2406, database is CAplus and MEDLINE.
The 1,2,4-benzothiadiazine 1,1-dioxide type of pos. allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) are promising lead compounds for the treatment of cognitive disorders, e.g., Alzheimer’s disease. The modulators bind in a cleft formed by the interface of 2 neighboring ligand binding domains and act by stabilizing the agonist-bound open-channel conformation. The driving forces behind the binding of these modulators can be significantly altered with only minor substitutions to the parent mols. Here, the authors show that changing the 7-F substituent of modulators BPAM 97 (I) and BPAM 344 (II) into a OH group (BPAM 557 (III) and BPAM 521 (IV), resp.), leads to a more favorable binding enthalpy (ΔH, kcal/mol) from -4.9 for I and -7.5 for II to -6.2 for III and -14.5 for IV, but also a less favorable binding entropy (-TΔS, kcal/mol) from -2.3 for I and -1.3 for II to -0.5 for III and 4.8 for IV. Thus, the dissociation constants (Kd, μM) of III (11.2) and IV (0.16) were similar to those of I (5.6) and II (0.35). Functionally, III and IV potentiated responses of 10 μM
Biophysical Journal published new progress about 1204572-55-3. 1204572-55-3 belongs to thiazole, auxiliary class Neuronal Signaling,GluR, name is 4-Cyclopropyl-7-fluoro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide, and the molecular formula is C10H11FN2O2S, Category: thiazole.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica