Liebig, H. published the artcileExperimental results with systematically synthesized substances for antiviral chemotherapy. 4. Role of physical binding in the synthesis of antiviral chemotherapeutics and its influence on potential mutagenic effects, Application of 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Arzneimittel-Forschung (1975), 25(11), 1716-22, database is CAplus and MEDLINE.
Of 13 antiviral substances containing specific hydrogen bridge linkage systems of the classes of 2-substituted 4-phenylthiazoles, 4-phenylimidazoles, and 1,3-indandiones tested for mutagenicity in the host-mediated assay, in bone marrow of rats, in spermatogonia of mice, and in the micronucleus test in rats, only N1-methyl-N2-(4-phenylthiazol-2-yl)urea (I) [52968-02-2] was mutagenic. Thus, the antiviral effectiveness of these substances was not caused by a chem. change in the coding system but by formation of phys. linkages like H bridge complexes with coding structures.
Arzneimittel-Forschung published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Application of 4-(Naphthalen-1-yl)thiazol-2-amine.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica