Day: November 21, 2022

Alberti, Guido published the artcileCationic dyes for acrylic fibers. IV. Cationic dyes from 6-methyl-2-(p-aminophenyl)benzothiazole and angular 2-aminonaphthothiazoles, Formula: C14H12N2S, the publication is Chimica e l’Industria (Milan, Italy) (1974), 56(10), 684-6, database is CAplus.

Leacril 16 acrylic fiber was dyed with a series of quaternized azo dyes based on 6-methyl-2-(p-aminophenyl)benzothiazole [92-36-4] and 2-aminonaphthothiazoles (I,II,III, R = H, Me; R1 = OH, CN; X = iodine, MeSO4). The greatest affinity was observed for dyes containing CH2CH2CN groups and based on naphthothiazoles. The rate of dyeing was greatest for dyes of type I. In aqueous solution the quaternized dyes had λ maximum 460-607 nm compared with 434-532 nm for the unquaternized compounds

Chimica e l’Industria (Milan, Italy) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Alberti, G. published the artcileSubstantivity of some heterocyclic amine derivative azo dyes, SDS of cas: 92-36-4, the publication is Rendiconti del Seminario della Facolta di Scienze dell’Universita di Cagliari (1976), 46(3-4), 213-23, database is CAplus.

The substantivities (-Δμ°), determined at 100° for I (R = H, Me; Z = N:N, C6H4N:N, NHC6H4N:N; R1 = R acid, chromotropic acid, H acid, γ acid residue) on cotton and viscose rayon by the technique of R.H. Peters and T. Vickerstaff (1954) were in good agreement with the Rf and Rm values determined by paper chromatog. The dyes examined were prepared by diazotization and coupling of 2-aminobenzothiazole [136-95-8], 6-methyl-2-(p-aminophenyl)benzothiazole [92-36-4], and 2-(p-aminoanilino)benzothiazole [5677-17-8] with the acids.

Rendiconti del Seminario della Facolta di Scienze dell’Universita di Cagliari published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, SDS of cas: 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Parra-Riofrio, Geovanna published the artcileAdaptation of autotrophic to heterotrophic culture of Porphyridium purpureum (Bory) K.M. Drew & R.Ross: characterization of biomass and production of exopolysaccharides, COA of Formula: C18H24N6O6S4, the publication is Journal of Applied Phycology (2021), 33(6), 3603-3615, database is CAplus.

Microalgae are successfully adapted to different environments where they metabolize inorganic and, in some cases, organic compounds The modification of culture conditions can induce the synthesis of exopolysaccharides with potential health benefits. This study aims to adapt the autotrophic culture of the red alga Porphyridium purpureum to a heterotrophic culture in order to compare the biochem. composition of biomass and the production of exopolysaccharides (EPS). The adaptation of autotrophic to heterotrophic culture was carried out by progressively reducing the photoperiod and adding glucose. EPS extraction and purification were carried out. EPS were characterized by Fourier transform IR spectroscopy and gas chromatog.-mass spectrometry. The antioxidant capacity of both biomasses was analyzed by the 2,2-azino-bis (3- ethylbenzothiazoline-6-sulfonic acid) (ABTS) method and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Anal. for both biomass and EPS showed significant differences in biochem. composition and antioxidant activity under the two growing conditions. Furthermore, the heterotrophic EPS (HT-EPS) seems to favor the accumulation of glucuronic acid. Our results are the first adaptation from autotrophic to heterotrophic culture of P. purpureum. These trophic variations show that P. purpureum can adapt to heterotrophic culture and present interesting differences in its biochem. composition, being an alternative in the increase of metabolites, mainly carbon compounds, of interest to the industry.

Journal of Applied Phycology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, COA of Formula: C18H24N6O6S4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wu, Chunying published the artcileLipophilic analogs of thioflavin S as novel amyloid-imaging agents, Synthetic Route of 92-36-4, the publication is Current Alzheimer Research (2006), 3(3), 259-266, database is CAplus and MEDLINE.

Lipophilic analogs of thioflavin S were synthesized and radiolabeled with positron or single photon emitting radionuclides. The binding affinity for Aβ was evaluated using isolated amyloid fibrils from human brain tissue. Binding specificity was assessed using fluorescent tissue staining. In vivo brain uptake was evaluated in mice. Following synthesis, neutral analogs of thioflavin S capable of radiolabeling with ¹¹C or ¹²⁵I, were found to bind isolated human Aβ with affinities in the nanomolar range. Fluorescent tissue staining showed selective binding to Aβ deposits in vitro. Biodistribution of selected compounds displayed high brain permeability at early time points. At later points, the compounds were cleared from the normal brain, indicating low non-specific binding in vivo. These studies indicated that novel amyloid imaging probes can be developed based on thioflavin S that readily entered the brain and selectively bound to Aβ deposits and neurofibrilary tangles. Potential applications of these amyloid binding agents include facilitating drug screening in animal models and use as in vivo markers of early and definitive diagnosis of AD.

Current Alzheimer Research published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C8H5F3N4, Synthetic Route of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Mugherli, Laurent published the artcileIn Situ Assembly and Screening of Enzyme Inhibitors with Surface-Tension Microarrays, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate, the publication is Angewandte Chemie, International Edition (2009), 48(41), 7639-7644, database is CAplus and MEDLINE.

Hundreds of reactions were conducted in parallel in droplets maintained on a glass slide through differential surface tension in a new approach to submicroliter-scale synthesis. This surface-tension microarray was applied to the in situ assembly of thousands of derivatives of phenylboronic acid and their profiling against the NS3/4A protease of the hepatitis C virus. Several potent inhibitors of the enzyme were identified.

Angewandte Chemie, International Edition published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Toshniwal, Madhu published the artcileAntibacterial activity and greener method of synthesis of heterocyclic compounds incorporating benzothiazole moiety using ionic liquid as solvent, Safety of 6-Chlorobenzothiazol-2-ylamine, the publication is Rasayan Journal of Chemistry (2019), 12(3), 1294-1297, database is CAplus.

A novel series of substituted dimethylimidazo{2,1-b}[1,3]benzothiazoles have been synthesized by reaction of 2-amino-6-substituted benzothiazoles with halo ketone by conventional method as well as microwave conditions using ionic liquids The yield of products obtained by microwave synthesis with ionic liquids is much better than the conventional method. The reported compounds were further screened for their antibacterial activity using ampicillin as standard drug. The compounds showed excellent activity against Pseudomonas Aeruginosa, Klebsiella pneumonia and Staphylococcus aureus.

Rasayan Journal of Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H9BO3, Safety of 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Trofymchuk, Serhii published the artcileScalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF₄), Recommanded Product: 1-(2-Chlorothiazol-5-yl)ethanone, the publication is Journal of Organic Chemistry (2021), 86(17), 12181-12198, database is CAplus and MEDLINE.

A general approach to fluorinated (hetero)aromatic derivatives was elaborated. The key reaction was a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF₄). In contrast to previous deoxofluorination methods, this transformation was fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chem. and agrochem., were synthesized.

Journal of Organic Chemistry published new progress about 885229-41-4. 885229-41-4 belongs to thiazole, auxiliary class Thiazole,Chloride,Ketone, name is 1-(2-Chlorothiazol-5-yl)ethanone, and the molecular formula is C17H26BNO3, Recommanded Product: 1-(2-Chlorothiazol-5-yl)ethanone.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kucukbay, F. Zehra published the artcileSynthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2016), 31(6), 1221-1225, database is CAplus and MEDLINE.

N-protected amino acids I [Pg = Cbz, Boc, R = H, Me; Pg =Boc, R = CH₂Ph] were reacted with substituted benzothiazoles to give the corresponding N-protected amino acid-benzothiazole conjugates II [Pg = Cbz, R = H; Pg = Boc, R = H, CH₂Ph], III [Pg = Cbz, R = H, Me; Pg = Boc, R = H, CH₂Ph] and IV [Pg = CBz, R = H, Me; Pg = Boc, R = H, Me, CH₂Ph] (60-89%). Their structures were confirmed by proton NMR (¹H NMR), carbon-13 NMR (¹³C NMR), IR and elemental anal. Their carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activities were determined against two cytosolic human isoforms (hCA I and hCA II), one membrane-associated (hCA IV) and one transmembrane (hCA XII) enzyme by a stopped-flow CO₂ hydrase assay method. The new compounds showed rather weak, micromolar inhibitory activity against most of these enzymes.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Leng, Yan published the artcileA colorimetric immunosensor based on Hemin@MI nanozyme composites, with peroxidase-like activity for point-of-care testing of pathogenic E. coli O157:H7, Name: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Analytical Sciences (2021), 37(7), 941-947, database is CAplus and MEDLINE.

Recently, nanozymes have become a topic of particular interest due to their high activity level, stability and biocompatibility. In this study, a visual, sensitive and selective point-of-care immunosensor was established to test the pathogen Escherichia coli O157:H7 (E. coli O157:H7). Hemin and magainin I (MI) hybrid nanocomposites (Hemin@MI) with peroxidase-mimicking activities were synthesized via a “one-pot” method, involving the simple mixing of an antimicrobial peptide (MI) against E. coli O157:H7 and hemin in a copper sulfate sodium phosphate saline buffer. Hemin@MI nanocomposites integrating target recognition and signal amplification were developed as signal probes for the point-ofcare colorimetric detection of pathogenic E. coli O157:H7. Hemin@MI nanocomposites exhibit excellent peroxidase activity for the chromogenic reaction of ABTS, which allows for the visual point-of-care testing of E. coli O157:H7 in the range of 102 to 108 CFU/mL, with a limit of detection of 85 CFU/mL. These data suggest this immunosensor provides accessible and portable assessments of pathogenic E. coli O157:H7 in real samples.

Analytical Sciences published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Name: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Capule, Christina C. published the artcileOligovalent Amyloid-Binding Agents Reduce SEVI-Mediated Enhancement of HIV-1 Infection, Related Products of thiazole, the publication is Journal of the American Chemical Society (2012), 134(2), 905-908, database is CAplus and MEDLINE.

This paper evaluates the use of oligovalent amyloid-binding mols. as potential agents that can reduce the enhancement of human immunodeficiency virus-1 (HIV-1) infection in cells by semen-derived enhancer of virus infection (SEVI) fibrils. These naturally occurring amyloid fibrils found in semen have been implicated as mediators that can facilitate the attachment and internalization of HIV-1 virions to immune cells. Mols. that are capable of reducing the role of SEVI in HIV-1 infection may, therefore, represent a novel strategy to reduce the rate of sexual transmission of HIV-1 in humans. Here, we evaluated a set of synthetic, oligovalent derivatives of benzothiazole aniline (BTA, a known amyloid-binding mol.) for their capability to bind cooperatively to aggregated amyloid peptides and to neutralize the effects of SEVI in HIV-1 infection. We demonstrate that these BTA derivatives exhibit a general trend of increased binding to aggregated amyloids as a function of increasing valence number of the oligomer. Importantly, we find that oligomers of BTA show improved capability to reduce SEVI-mediated infection of HIV-1 in cells compared to a BTA monomer, with the pentamer exhibiting a 65-fold improvement in efficacy compared to a previously reported monomeric BTA derivative These results, thus, support the use of amyloid-targeting mols. as potential supplements for microbicides to curb the spread of HIV-1 through sexual contact.

Journal of the American Chemical Society published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica